Seroatlas · Human Serome Atlas

HOXB5

Homeobox protein Hox-B5

Also known as: HOX2, HOX2A, HXB5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P09067
Gene: HOXB5
Ensembl: ENSG00000120075
Chromosome: 17
Canonical length: 269 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli fibrillar center,Cytosol

OverviewNCBI Gene

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

269 residues, UniProt reviewed canonical sequence.

>P09067|HOXB5
     1  MSSYFVNSFS GRYPNGPDYQ LLNYGSGSSL SGSYRDPAAM HTGSYGYNYN GMDLSVNRSS
    61  ASSSHFGAVG ESSRAFPAPA QEPRFRQAAS SCSLSSPESL PCTNGDSHGA KPSASSPSDQ
   121  ATSASSSANF TEIDEASASS EPEEAASQLS SPSLARAQPE PMATSTAAPE GQTPQIFPWM
   181  RKLHISHDMT GPDGKRARTA YTRYQTLELE KEFHFNRYLT RRRRIEIAHA LCLSERQIKI
   241  WFQNRRMKWK KDNKLKSMSL ATAGSAFQP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HOXB5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

kidney: 33 nTPM
epididymis: 17 nTPM
colon: 17 nTPM
small intestine: 13 nTPM
spinal cord: 11 nTPM
fallopian tube: 7 nTPM

Single-cell type

endometrial secretory cells: 1 nCPM
kupffer cells: 1 nCPM
endometrial ciliated cells: 0.9 nCPM
endometrial luminal cells: 0.9 nCPM
thymocytes: 0.8 nCPM
endometrial glandular cells: 0.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 84 nTPM
spinal cord: 54 nTPM
pons: 23 nTPM
white matter: 19 nTPM
midbrain: 0.3 nTPM
cerebral cortex: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.58
gnomAD pLI: 0.7
gnomAD missense Z: 0.11
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HOXB5 as an antibody target. Whether an autoantibody or antibody against HOXB5 could matter depends on whether native HOXB5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HOXB5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HOXB5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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