Seroatlas · Human Serome Atlas

HOXA6

Homeobox protein Hox-A6

Also known as: HOX1, HOX1B, HXA6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P31267
Gene: HOXA6
Ensembl: ENSG00000106006
Chromosome: 7
Canonical length: 233 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear speckles

OverviewNCBI Gene

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

233 residues, UniProt reviewed canonical sequence.

>P31267|HOXA6
     1  MSSYFVNPTF PGSLPSGQDS FLGQLPLYQA GYDALRPFPA SYGASSLPDK TYTSPCFYQQ
    61  SNSVLACNRA SYEYGASCFY SDKDLSGASP SGSGKQRGPG DYLHFSPEQQ YKPDSSSGQG
   121  KALHDEGADR KYTSPVYPWM QRMNSCAGAV YGSHGRRGRQ TYTRYQTLEL EKEFHFNRYL
   181  TRRRRIEIAN ALCLTERQIK IWFQNRRMKW KKENKLINST QPSGEDSEAK AGE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HOXA6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 11 nTPM
colon: 6.2 nTPM
endometrium: 5.8 nTPM
kidney: 5.3 nTPM
small intestine: 4 nTPM
epididymis: 3.5 nTPM

Single-cell type

hematopoietic stem cells: 4.4 nCPM
endometrial stromal cells: 1.9 nCPM
prostatic club cells: 1.9 nCPM
basal prostatic cells: 1.8 nCPM
prostatic hillock cells: 1.6 nCPM
epididymal efferent duct absorptive cells: 1 nCPM

Immune cell

basophil: 3.1 nTPM
NK-cell: 0.9 nTPM
plasmacytoid DC: 0.2 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

spinal cord: 18 nTPM
medulla oblongata: 17 nTPM
white matter: 13 nTPM
pons: 5.3 nTPM
cerebral cortex: 1.8 nTPM
basal ganglia: 1.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.54
gnomAD pLI: 0
gnomAD missense Z: -0.1
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HOXA6 as an antibody target. Whether an autoantibody or antibody against HOXA6 could matter depends on whether native HOXA6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HOXA6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HOXA6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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