HOXA7
Homeobox protein Hox-A7
Also known as: HOX1, HOX1A, HXA7_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P31268
- Gene
- HOXA7
- Ensembl
- ENSG00000122592
- Chromosome
- 7
- Canonical length
- 230 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Nuclear membrane
OverviewNCBI Gene
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
230 residues, UniProt reviewed canonical sequence.
>P31268|HOXA7
1 MSSSYYVNAL FSKYTAGASL FQNAEPTSCS FAPNSQRSGY GAGAGAFAST VPGLYNVNSP
61 LYQSPFASGY GLGADAYGNL PCASYDQNIP GLCSDLAKGA CDKTDEGALH GAAEANFRIY
121 PWMRSSGPDR KRGRQTYTRY QTLELEKEFH FNRYLTRRRR IEIAHALCLT ERQIKIWFQN
181 RRMKWKKEHK DEGPTAAAAP EGAVPSAAAT AAADKADEED DDEEEEDEEELocalizationUniProt · AlphaFold · HPA
Whether an antibody against HOXA7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.65
- Highest tissue expression
- 21 nTPM
Expression across tissuesHPA
Tissue
- fallopian tube: 21 nTPM
- kidney: 20 nTPM
- adrenal gland: 17 nTPM
- epididymis: 17 nTPM
- skeletal muscle: 16 nTPM
- colon: 13 nTPM
Single-cell type
- oocytes: 92 nCPM
- epididymal efferent duct absorptive cells: 81 nCPM
- late primary spermatocytes: 63 nCPM
- epididymal principal cells: 35 nCPM
- smooth muscle cells: 35 nCPM
- epididymal clear cells: 33 nCPM
Immune cell
- NK-cell: 4.7 nTPM
- gdT-cell: 0.8 nTPM
- myeloid DC: 0.5 nTPM
- plasmacytoid DC: 0.3 nTPM
- T-reg: 0.2 nTPM
- memory B-cell: 0.1 nTPM
Brain region
- spinal cord: 18 nTPM
- white matter: 11 nTPM
- medulla oblongata: 10 nTPM
- pons: 2.8 nTPM
- cerebral cortex: 0.2 nTPM
- midbrain: 0.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.48
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.63
- DepMap mean gene effect
- 0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- angiogenesis
- anterior/posterior pattern specification
- embryonic skeletal system morphogenesis
- negative regulation of cell-matrix adhesion
- negative regulation of DNA-templated transcription
- negative regulation of keratinocyte differentiation
- negative regulation of leukocyte migration
- negative regulation of monocyte differentiation
- negative regulation of transcription by RNA polymerase II
- positive regulation of transcription by RNA polymerase II
- regulation of transcription by RNA polymerase II
- stem cell differentiation
Molecular functions
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription factor binding
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- sequence-specific double-stranded DNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads HOXA7 as an antibody target. Whether an autoantibody or antibody against HOXA7 could matter depends on whether native HOXA7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
HOXA7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label HOXA7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...