Cytochrome P450 family 2
IPR050182
Definition
The Cytochrome P450 2 family comprises enzymes involved in the metabolism of fatty acids, steroids, retinoids, and xenobiotics including Cytochrome P450 2E1 and Cytochrome P450 2D6 [[cite:PMID:10553002], [cite:PMID:18577768], [cite:PMID:21289075], [cite:PMID:21576599]]. They function as monooxygenases, catalysing the insertion of one oxygen atom from molecular oxygen into substrates, while reducing the second oxygen atom to water, using electrons from NADPH via cytochrome P450 reductase. Members of this family exhibit diverse substrate specificities, including hydroxylation of carbon-hydrogen bonds, epoxidation of double bonds, and metabolism of arachidonic acid and its conjugates. They are implicated in the synthesis of bile acids and steroid hormones, activation of vitamin D precursors, and the oxidative metabolism of various endogenous compounds and drugs. Some members also possess peroxidase and isomerase activities, modulating eicosanoid signalling and contributing to the breakdown of prostaglandins. The family plays a role in the regulation of physiological processes and the detoxification of potentially harmful substances.
18 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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