CYP2J2

Protein identityUniProt · HPA

UniProt accession

P51589

Gene

CYP2J2

Ensembl

ENSG00000134716

Chromosome

1

Canonical length

502 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Secretome location

Intracellular and membrane

OverviewNCBI Gene

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

502 residues, UniProt reviewed canonical sequence.

>P51589|CYP2J2
     1  MLAAMGSLAA ALWAVVHPRT LLLGTVAFLL AADFLKRRRP KNYPPGPWRL PFLGNFFLVD
    61  FEQSHLEVQL FVKKYGNLFS LELGDISAVL ITGLPLIKEA LIHMDQNFGN RPVTPMREHI
   121  FKKNGLIMSS GQAWKEQRRF TLTALRNFGL GKKSLEERIQ EEAQHLTEAI KEENGQPFDP
   181  HFKINNAVSN IICSITFGER FEYQDSWFQQ LLKLLDEVTY LEASKTCQLY NVFPWIMKFL
   241  PGPHQTLFSN WKKLKLFVSH MIDKHRKDWN PAETRDFIDA YLKEMSKHTG NPTSSFHEEN
   301  LICSTLDLFF AGTETTSTTL RWALLYMALY PEIQEKVQAE IDRVIGQGQQ PSTAARESMP
   361  YTNAVIHEVQ RMGNIIPLNV PREVTVDTTL AGYHLPKGTM ILTNLTALHR DPTEWATPDT
   421  FNPDHFLENG QFKKREAFMP FSIGKRACLG EQLARTELFI FFTSLMQKFT FRPPNNEKLS
   481  LKFRMGITIS PVSHRLCAVP QV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CYP2J2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.24

Highest tissue expression

137 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.39

gnomAD pLI

0

gnomAD missense Z

0.14

DepMap mean gene effect

0

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• epoxygenase P450 pathway
• fatty acid metabolic process
• icosanoid metabolic process
• linoleic acid metabolic process
• organic acid metabolic process
• regulation of heart contraction
• xenobiotic metabolic process

Molecular functions

• arachidonate 11,12-epoxygenase activity
• arachidonate 14,15-epoxygenase activity
• arachidonate epoxygenase activity
• heme binding
• hydroperoxy icosatetraenoate isomerase activity
• iron ion binding
• isomerase activity
• linoleic acid epoxygenase activity
• monooxygenase activity
• oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
• arachidonate 5,6-epoxygenase activity

Cellular components

• cytoplasm
• endoplasmic reticulum membrane
• extracellular exosome

Protein domainsUniProt · Pfam · InterPro

• Cytochrome P450
• Cytochrome P450, E-class, group I
• Cytochrome P450, conserved site
• Cytochrome P450 superfamily
• Cytochrome P450 family 2
• Cytochrome P450
• Cytochrome P450, E-class, group I, CYP2J-like

KeywordsUniProt

• Endoplasmic reticulum
• Fatty acid metabolism
• Heme
• Iron
• Isomerase
• Lipid metabolism
• Membrane
• Metal-binding
• Microsome
• Monooxygenase
• Oxidoreductase