Seroatlas · Human Serome Atlas

CYP2S1

Cytochrome P450 2S1

Also known as: CP2S1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96SQ9
Gene
CYP2S1
Ensembl
ENSG00000167600
Chromosome
19
Canonical length
504 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Endoplasmic reticulum

OverviewNCBI Gene

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

504 residues, UniProt reviewed canonical sequence.

>Q96SQ9|CYP2S1
     1  MEATGTWALL LALALLLLLT LALSGTRARG HLPPGPTPLP LLGNLLQLRP GALYSGLMRL
    61  SKKYGPVFTI YLGPWRPVVV LVGQEAVREA LGGQAEEFSG RGTVAMLEGT FDGHGVFFSN
   121  GERWRQLRKF TMLALRDLGM GKREGEELIQ AEARCLVETF QGTEGRPFDP SLLLAQATSN
   181  VVCSLLFGLR FSYEDKEFQA VVRAAGGTLL GVSSQGGQTY EMFSWFLRPL PGPHKQLLHH
   241  VSTLAAFTVR QVQQHQGNLD ASGPARDLVD AFLLKMAQEE QNPGTEFTNK NMLMTVIYLL
   301  FAGTMTVSTT VGYTLLLLMK YPHVQKWVRE ELNRELGAGQ APSLGDRTRL PYTDAVLHEA
   361  QRLLALVPMG IPRTLMRTTR FRGYTLPQGT EVFPLLGSIL HDPNIFKHPE EFNPDRFLDA
   421  DGRFRKHEAF LPFSLGKRVC LGEGLAKAEL FLFFTTILQA FSLESPCPPD TLSLKPTVSG
   481  LFNIPPAFQL QVRPTDLHST TQTR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CYP2S1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
114 nTPM

Expression across tissuesHPA

Tissue

  • stomach: 114 nTPM
  • duodenum: 95 nTPM
  • small intestine: 62 nTPM
  • colon: 25 nTPM
  • rectum: 17 nTPM
  • esophagus: 15 nTPM

Single-cell type

  • foveolar cells: 232 nCPM
  • cdc: 61 nCPM
  • enterocytes: 58 nCPM
  • respiratory basal cells: 46 nCPM
  • goblet cells: 40 nCPM
  • cytotrophoblasts: 31 nCPM

Immune cell

  • myeloid DC: 85 nTPM
  • classical monocyte: 25 nTPM
  • total PBMC: 11 nTPM
  • intermediate monocyte: 5.9 nTPM
  • non-classical monocyte: 3.8 nTPM
  • plasmacytoid DC: 3.2 nTPM

Brain region

  • midbrain: 21 nTPM
  • pons: 12 nTPM
  • medulla oblongata: 8.7 nTPM
  • hypothalamus: 8 nTPM
  • thalamus: 6.9 nTPM
  • cerebellum: 5.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.89
gnomAD pLI
0
gnomAD missense Z
0.92
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CYP2S1 as an antibody target. Whether an autoantibody or antibody against CYP2S1 could matter depends on whether native CYP2S1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CYP2S1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CYP2S1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CYP2S1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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