Seroatlas · Human Serome Atlas

CYP2D7

Cytochrome P450 2D7

Also known as: CP2D7_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A087X1C5
Gene: CYP2D7
Canonical length: 515 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for CYP2D7 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

515 residues, UniProt reviewed canonical sequence.

>A0A087X1C5|CYP2D7
     1  MGLEALVPLA MIVAIFLLLV DLMHRHQRWA ARYPPGPLPL PGLGNLLHVD FQNTPYCFDQ
    61  LRRRFGDVFS LQLAWTPVVV LNGLAAVREA MVTRGEDTAD RPPAPIYQVL GFGPRSQGVI
   121  LSRYGPAWRE QRRFSVSTLR NLGLGKKSLE QWVTEEAACL CAAFADQAGR PFRPNGLLDK
   181  AVSNVIASLT CGRRFEYDDP RFLRLLDLAQ EGLKEESGFL REVLNAVPVL PHIPALAGKV
   241  LRFQKAFLTQ LDELLTEHRM TWDPAQPPRD LTEAFLAKKE KAKGSPESSF NDENLRIVVG
   301  NLFLAGMVTT STTLAWGLLL MILHLDVQRG RRVSPGCPIV GTHVCPVRVQ QEIDDVIGQV
   361  RRPEMGDQAH MPCTTAVIHE VQHFGDIVPL GVTHMTSRDI EVQGFRIPKG TTLITNLSSV
   421  LKDEAVWKKP FRFHPEHFLD AQGHFVKPEA FLPFSAGRRA CLGEPLARME LFLFFTSLLQ
   481  HFSFSVAAGQ PRPSHSRVVS FLVTPSPYEL CAVPR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CYP2D7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 0 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
appendix: 0 nTPM
bone marrow: 0 nTPM
breast: 0 nTPM
cerebral cortex: 0 nTPM

Single-cell type

enterocytes: 168 nCPM
late spermatids: 5.5 nCPM
hepatocytes: 4.6 nCPM
bergmann glia: 4.2 nCPM
other brain neurons: 4.2 nCPM
brain inhibitory neurons: 3.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CYP2D7 as an antibody target. Whether an autoantibody or antibody against CYP2D7 could matter depends on whether native CYP2D7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CYP2D7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CYP2D7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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