Seroatlas · Human Serome Atlas

CYP2W1

Cytochrome P450 2W1

Also known as: CP2W1_HUMAN, FLJ20359, MGC34287

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TAV3
Gene: CYP2W1
Ensembl: ENSG00000073067
Chromosome: 7
Canonical length: 490 aa
Protein class: Predicted intracellular proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

490 residues, UniProt reviewed canonical sequence.

>Q8TAV3|CYP2W1
     1  MALLLLLFLG LLGLWGLLCA CAQDPSPAAR WPPGPRPLPL VGNLHLLRLS QQDRSLMELS
    61  ERYGPVFTVH LGRQKTVVLT GFEAVKEALA GPGQELADRP PIAIFQLIQR GGGIFFSSGA
   121  RWRAARQFTV RALHSLGVGR EPVADKILQE LKCLSGQLDG YRGRPFPLAL LGWAPSNITF
   181  ALLFGRRFDY RDPVFVSLLG LIDEVMVLLG SPGLQLFNVY PWLGALLQLH RPVLRKIEEV
   241  RAILRTLLEA RRPHVCPGDP VCSYVDALIQ QGQGDDPEGL FAEANAVACT LDMVMAGTET
   301  TSATLQWAAL LMGRHPDVQG RVQEELDRVL GPGRTPRLED QQALPYTSAV LHEVQRFITL
   361  LPHVPRCTAA DTQLGGFLLP KGTPVIPLLT SVLLDETQWQ TPGQFNPGHF LDANGHFVKR
   421  EAFLPFSAGR RVCVGERLAR TELFLLFAGL LQRYRLLPPP GVSPASLDTT PARAFTMRPR
   481  AQALCAVPRP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CYP2W1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 19 nTPM
skin: 10 nTPM
duodenum: 5.8 nTPM
prostate: 2.1 nTPM
ovary: 1.3 nTPM
small intestine: 1 nTPM

Single-cell type

gastric progenitor cells: 51 nCPM
neuroendocrine cells: 43 nCPM
enteric stem cells: 33 nCPM
prostatic hillock cells: 14 nCPM
adrenal cortex cells: 12 nCPM
müller glia: 11 nCPM

Immune cell

basophil: 0.3 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 1.1 nTPM
cerebral cortex: 1 nTPM
pons: 0.9 nTPM
white matter: 0.9 nTPM
basal ganglia: 0.8 nTPM
medulla oblongata: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.1
gnomAD pLI: 0
gnomAD missense Z: 0.17
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CYP2W1 as an antibody target. Whether an autoantibody or antibody against CYP2W1 could matter depends on whether native CYP2W1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CYP2W1 is annotated at the cell surface, where native CYP2W1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CYP2W1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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