Seroatlas · Human Serome Atlas

PNMA6F

Paraneoplastic antigen Ma6F

Also known as: PMA6F_HUMAN, PNMA6BL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A0J9YX94
Gene: PNMA6F
Ensembl: ENSG00000225110
Chromosome: X
Canonical length: 578 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for PNMA6F in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

578 residues, UniProt reviewed canonical sequence.

>A0A0J9YX94|PNMA6F
     1  MLQDWCRRMG VNAERSLLIL DIPDDCEEHE FQEAVRAALS PLGRYRVLIK VFRKELGARA
    61  ALVEFAEGLN QSLIPRQIAG KGGPWKVISL PQALDAEFQD IPSFPAQPQG QAVARGAGEA
   121  GAAGEAGSVG EAGGVNEERS AGEDEAGGIG EAGGVGEAGA AGEAGAAGEA GAAGEAGGAG
   181  EAGGAGEAGG AGEEGGTGEE GGAGEAGGAG EEGGEDEAGA AGEAVGAGVV EAWTQSWRQT
   241  LRPLVKTMAY RELRPFSGRE QPGCVEESFE SWLEDAKDML QLWCHASERE RRRRLLDSLD
   301  GLALDIVSGL LEEDPDFSAQ DCLTALGQVF RSRDTWMTSR MKFLTCTQGP QEGLFAFVVR
   361  LEGLLQKAVE KGAVHPAMAN HLRLRQVLSR ARPSEALQDT LRRMQLERRP PDFLRLLRLI
   421  RDMEAWAASL ARSQQGVAWA AAPVESEDPA AAQASPAQGD ASEADPGAED ADEAASTTKE
   481  AARVAPATGE DENAPAGLEG LGQGRSPDAP GGLPARMGSA VDMAPGGPSW EPEGLVQVGG
   541  QEAEEPPQEG LKPILEESEN EDEDGAGEAG KPKSPPGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PNMA6F can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 25 nTPM
cerebral cortex: 7.5 nTPM
basal ganglia: 6.6 nTPM
amygdala: 3.9 nTPM
midbrain: 2.8 nTPM
hippocampal formation: 2.6 nTPM

Single-cell type

other brain neurons: 14 nCPM
brain inhibitory neurons: 3.8 nCPM
brain excitatory neurons: 3.2 nCPM
somatotrophs: 2.2 nCPM
pituitary stem cells: 1.8 nCPM
thyrotrophs: 0.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 55 nTPM
pons: 28 nTPM
basal ganglia: 23 nTPM
midbrain: 16 nTPM
cerebral cortex: 16 nTPM
thalamus: 13 nTPM

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PNMA6F as an antibody target. Whether an autoantibody or antibody against PNMA6F could matter depends on whether native PNMA6F is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PNMA6F is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PNMA6F as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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