Seroatlas · Human Serome Atlas

PNMA6A

Paraneoplastic antigen-like protein 6A

Also known as: MGC15827, PNM6A_HUMAN, PNMA6C

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0CW24
Gene: PNMA6A
Ensembl: ENSG00000235961
Chromosome: X
Canonical length: 399 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

No narrative summary is available for PNMA6A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

399 residues, UniProt reviewed canonical sequence.

>P0CW24|PNMA6A
     1  MAVTMLQDWC RWMGVNARRG LLILGIPEDC DDAEFQESLE AALRPMGHFT VLGKAFREED
    61  NATAALVELD REVNYALVPR EIPGTGGPWN VVFVPRCSGE EFLGLGRVFH FPEQEGQMVE
   121  SVAGALGVGL RRVCWLRSIG QAVQPWVEAV RCQSLGVFSG RDQPAPGEES FEVWLDHTTE
   181  MLHVWQGVSE RERRRRLLEG LRGTALQLVH ALLAENPART AQDCLAALAQ VFGDNESQAT
   241  IRVKCLTAQQ QSGERLSAFV LRLEVLLQKA MEKEALARAS ADRVRLRQML TRAHLTEPLD
   301  EALRKLRMAG RSPSFLEMLG LVRESEAWEA SLARSVRAQT QEGAGARAGA QAVARASTKV
   361  EAVPGGPGRE PEGLLQAGGQ EAEELLQEGL KPVLEECDN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PNMA6A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 39 nTPM
hypothalamus: 27 nTPM
amygdala: 19 nTPM
cerebellum: 18 nTPM
hippocampal formation: 16 nTPM
basal ganglia: 15 nTPM

Single-cell type

epididymal principal cells: 55 nCPM
retinal amacrine cells: 35 nCPM
epididymal efferent duct absorptive cells: 25 nCPM
tuft cells: 23 nCPM
other brain neurons: 19 nCPM
respiratory ionocytes: 18 nCPM

Immune cell

eosinophil: 2 nTPM
neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 54 nTPM
basal ganglia: 34 nTPM
hypothalamus: 34 nTPM
white matter: 33 nTPM
pons: 32 nTPM
thalamus: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

InteractionsUniProt · HPA

Protein binding partners of PNMA6A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PNMA1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PNMA6A as an antibody target. Whether an autoantibody or antibody against PNMA6A could matter depends on whether native PNMA6A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PNMA6A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PNMA6A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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