Seroatlas · Human Serome Atlas

PNMA6E

Paraneoplastic antigen Ma6E

Also known as: PMA6E_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A0J9YXQ4
Gene: PNMA6E
Ensembl: ENSG00000214897
Chromosome: X
Canonical length: 647 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for PNMA6E in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

647 residues, UniProt reviewed canonical sequence.

>A0A0J9YXQ4|PNMA6E
     1  MALAMLRDWC RWMGANAERS LLILGIPDDC KEHEFQEAVR AALSPLGRYR VLTKHFRKEL
    61  GAKAALVEFA EYLNRSLIPH QIPGNGGPWK VIFLPQVPVI EFQDMPSFPA QPQGQAVAKA
   121  AGEGGGAGEA GGVGEVGAAG EAGGTGEAGA TGEAGAAGEA GGAGEAGGVG EAGAAGEAGG
   181  AGEAGAAGEG GAAGEAGGAG EAGGVGEAGA AGEAGGAGEA GGVGEAGAAG EAGGAGEAGA
   241  AGEAGGAGEG RAAGEAGAAG EAGAVGEAGA AGEAGAVGEA GAAGEAGAVG EAGGTNVTKA
   301  WVQPWRCTLQ PVLENRAYRE LRPFSRREQP GCEEESFESW VEHAKDMLQL WCHASEREKK
   361  RWLLESLGGP ALEVVSGLLE EDTNLSALDC LAALGQVFRN QDTRMTSRLK FLTCTQGPQE
   421  GLFAFVVRLE GLLQRAVEKG AVCPALANYL RLQQVLSWAR PSEALQDTLR GMQLEKRPPG
   481  FLGLLRLIRE MEAWAAFPAR SQQGVAWAAA PVESEDPAAA QASPAQGNAS EAGPGAEDAA
   541  EAASATKEAA RGAPAAGEGE SAPAGPEGLG QARPIEVPWG SSPARMSSAV WVFPRGLSWG
   601  PEGLIQVRGQ EARKPPLEGL QTILEEPENE DEDGAGDEGQ PKSSQGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PNMA6E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 9.2 nTPM

Expression across tissuesHPA

Tissue

testis: 9.2 nTPM
epididymis: 3 nTPM
ovary: 1.9 nTPM
fallopian tube: 0.4 nTPM
pituitary gland: 0.2 nTPM
adrenal gland: 0.1 nTPM

Single-cell type

early primary spermatocytes: 50 nCPM
differentiating spermatogonia: 22 nCPM
peritubular myoid cells: 3.8 nCPM
fibroblasts: 2 nCPM
late primary spermatocytes: 1.3 nCPM
leydig cells: 0.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PNMA6E as an antibody target. Whether an autoantibody or antibody against PNMA6E could matter depends on whether native PNMA6E is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PNMA6E is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PNMA6E as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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