Seroatlas · Human Serome Atlas

ZCCHC18

Zinc finger CCHC domain-containing protein 18

Also known as: PNMA7B, SIZN2, ZCC18_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0CG32
Gene: ZCCHC18
Ensembl: ENSG00000166707
Chromosome: X
Canonical length: 403 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

403 residues, UniProt reviewed canonical sequence.

>P0CG32|ZCCHC18
     1  MASITACVGN SRQQNAPLPP WAHSMLRSLG RSLCPLVVKM AERNMKLFSG RVVPAQGKET
    61  FENWLIQVNE VLPDWSMSEE EKLKRLMKTL RGPAREVMRL LQAANPNLSV ADFLRAMKLV
   121  FGESESSVTA HGKFFNTLQA QGEKASLYVI RLEVQLQNAI QAGILAEKDA NQTRLQQLLL
   181  GAELNRDLRF RLKHLLRMYA NKQERLPNFL ELIKMIREEE DWDDAFIKRK RPKRSEPIME
   241  RAASPVAFQG AQPIAISSAD CNCNVIEIDD TLDDSDEDVI LVVSLYPSLT PTGAPPFRGR
   301  ARPLDQVLVI DSPNNSGAQS LSTSGGSGYK NDGPGNIRRA RKRKYTTRCS YCGEEGHSKE
   361  TCDNESNKAQ VFENLIITLQ ELTHTEERSK EVPGEHSDAS EPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZCCHC18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 5.4 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 5.4 nTPM
hypothalamus: 4.8 nTPM
ovary: 4.1 nTPM
basal ganglia: 3.1 nTPM
cerebral cortex: 3 nTPM
amygdala: 2.2 nTPM

Single-cell type

adrenal medulla cells: 11 nCPM
other brain neurons: 6.9 nCPM
astrocytes: 6.1 nCPM
pancreatic islet cells: 5.5 nCPM
bergmann glia: 5.4 nCPM
ependymal cells: 4.7 nCPM

Immune cell

naive B-cell: 0.8 nTPM
memory B-cell: 0.7 nTPM
MAIT T-cell: 0.6 nTPM
memory CD8 T-cell: 0.5 nTPM
gdT-cell: 0.4 nTPM
naive CD8 T-cell: 0.4 nTPM

Brain region

hypothalamus: 9 nTPM
basal ganglia: 4.6 nTPM
cerebellum: 4.4 nTPM
cerebral cortex: 4.2 nTPM
midbrain: 3.7 nTPM
hippocampal formation: 3.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0.41
gnomAD missense Z: 0.75
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

zinc ion binding

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZCCHC18 as an antibody target. Whether an autoantibody or antibody against ZCCHC18 could matter depends on whether native ZCCHC18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZCCHC18 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZCCHC18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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