RNA exonuclease REXO1/REXO3/REXO4-like

Definition

This entry represents a family of eukaryotic proteins that function as exonucleases, including RNA exonuclease 1 homologue from humans (REXO1), RNA exonuclease 3 from Candida albicans, RNA exonuclease 4 from Saccharomyces cerevisiae (REXO4), and Putative small RNA degrading nuclease 1-5 from Arabidopsis thaliana (SDN1-5), all of which appear to have exonuclease activity [[cite:PMID:18787168], [cite:PMID:10716935]]. Interferon-stimulated gene 20 kDa proteins from mammals (also known as apoptosis-enhancing nuclease AEN) also included in this family, which are exonucleases with activity against single- and double-stranded DNA and RNA and mediates p53-induced apoptosis PMID:18264133. They act also as interferon-induced antiviral exoribonucleases PMID:12594219.

7 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (7 proteins: gene, accession, name)

• AEN
• ISG20
• ISG20L2
• REXO1
• REXO1L1P
• REXO4
• REXO5