Transferrin receptor protein 1/Glutamate carboxypeptidase 2-like

Definition

This entry includes glutamate carboxypeptidase 2 (FOLH1) and its homologues from peptidase family M28 subfamily B. Not all members of this subfamily are peptidases, and non-peptidase homologues include transferrin receptor proteins (TFRC). FOLH1 is a zinc-dependent carboxypeptidase that also acts as a folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase). It has a preference for tri-alpha-glutamate peptides PMID:18234225. It is required for the uptake of folate in the intestine, and in the brain modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), releasing glutamate. Two zinc ions are bound per molecule PMID:16467855. TFRC acts as a lipid sensor, controlling the fusion of mitochondria by modulating the activation of the JNK pathway PMID:26214738.

7 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (7 proteins: gene, accession, name)

• FOLH1
• FOLH1B
• NAALAD2
• NAALADL1
• NAALADL2
• TFR2
• TFRC