Seroatlas · Human Serome Atlas

FOLH1B

Putative N-acetylated-alpha-linked acidic dipeptidase

Also known as: FOH1B_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HBA9
Gene: FOLH1B
Canonical length: 442 aa

OverviewNCBI Gene

No narrative summary is available for FOLH1B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

442 residues, UniProt reviewed canonical sequence.

>Q9HBA9|FOLH1B
     1  MGGSAPPDSS WRGSLKVSYN VGPGFTGNFS TQKVKMHIHS TNEVTRIYNV IGTLRGAVEP
    61  DRYVILGGHR DSWVFGGIDP QSGAAVVHET VRSFGTLKKE GWRPRRTILF ASWDAEEFGL
   121  LGSTEWAEDN SRLLQERGVA YINADSSIEG NYTLRVDCTP LMYSLVYNLT KELKSPDEGF
   181  EGKSLYESWT KKSPSPEFSG MPRISKLGSG NDFEVFFQRL GIASGRARYT KNWETNKFSG
   241  YPLYHSVYET YELVEKFYDP MFKYHLTVAQ VRGGMVFELA NSIVLPFDCR DYAVVLRKYA
   301  DKIYNISMKH PQEMKTYSLS FDSLFSAVKN FTEIASKFSE RLQDFDKSNP ILLRMMNDQL
   361  MFLERAFIDP LGLPDRPFYR HVIYAPSSHN KYAGESFPGI YDALFDIESK VDPSKAWGDV
   421  KRQISVAAFT VQAAAETLSE VA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FOLH1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FOLH1B.

Disease | ImmuneIEDB

Conditions an epitope on FOLH1B was assayed in.

prostate cancer B and T cell
prostate adenocarcinoma T cell

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FOLH1B as an antibody target. Whether an autoantibody or antibody against FOLH1B could matter depends on whether native FOLH1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FOLH1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FOLH1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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