Seroatlas · Human Serome Atlas

NAALADL2

Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2

Also known as: NADL2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q58DX5
Gene: NAALADL2
Ensembl: ENSG00000177694
Chromosome: 3
Canonical length: 795 aa
Protein class: Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to act upstream of or within response to bacterium. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

795 residues, UniProt reviewed canonical sequence.

>Q58DX5|NAALADL2
     1  MGENEASLPN TSLQGKKMAY QKVHADQRAP GHSQYLDNDD LQATALDLEW DMEKELEESG
    61  FDQFQLDGAE NQNLGHSETI DLNLDSIQPA TSPKGRFQRL QEESDYITHY TRSAPKSNRC
   121  NFCHVLKILC TATILFIFGI LIGYYVHTNC PSDAPSSGTV DPQLYQEILK TIQAEDIKKS
   181  FRNLVQLYKN EDDMEISKKI KTQWTSLGLE DVQFVNYSVL LDLPGPSPST VTLSSSGQCF
   241  HPNGQPCSEE ARKDSSQDLL YSYAAYSAKG TLKAEVIDVS YGMADDLKRI RKIKNVTNQI
   301  ALLKLGKLPL LYKLSSLEKA GFGGVLLYID PCDLPKTVNP SHDTFMVSLN PGGDPSTPGY
   361  PSVDESFRQS RSNLTSLLVQ PISAPLVAKL ISSPKARTKN EACSSLELPN NEIRVVSMQV
   421  QTVTKLKTVT NVVGFVMGLT SPDRYIIVGS HHHTAHSYNG QEWASSTAII TAFIRALMSK
   481  VKRGWRPDRT IVFCSWGGTA FGNIGSYEWG EDFKKVLQKN VVAYISLHSP IRGNSSLYPV
   541  ASPSLQQLVV EKNNFNCTRR AQCPETNISS IQIQGDADYF INHLGVPIVQ FAYEDIKTLE
   601  GPSFLSEARF STRATKIEEM DPSFNLHETI TKLSGEVILQ IANEPVLPFN ALDIALEVQN
   661  NLKGDQPNTH QLLAMALRLR ESAELFQSDE MRPANDPKER APIRIRMLND ILQDMEKSFL
   721  VKQAPPGFYR NILYHLDEKT SRFSILIEAW EHCKPLASNE TLQEALSEVL NSINSAQVYF
   781  KAGLDVFKSV LDGKN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NAALADL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 9.6 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 9.6 nTPM
cervix: 5.9 nTPM
breast: 5.5 nTPM
salivary gland: 5.4 nTPM
epididymis: 5.2 nTPM
prostate: 4.6 nTPM

Single-cell type

renal connecting tubule cells: 1,616 nCPM
salivary acinar cells: 1,321 nCPM
distal convoluted tubule cells: 1,265 nCPM
lacrimal acinar cells: 1,168 nCPM
fibro-adipogenic progenitors: 1,070 nCPM
renal collecting duct principal cells: 1,025 nCPM

Immune cell

plasmacytoid DC: 0.4 nTPM
naive CD4 T-cell: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

white matter: 11 nTPM
basal ganglia: 9.4 nTPM
medulla oblongata: 9.4 nTPM
pons: 8.2 nTPM
thalamus: 8 nTPM
cerebral cortex: 7.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.71
gnomAD pLI: 0
gnomAD missense Z: -1.82
DepMap mean gene effect: 0.15
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

response to bacterium

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NAALADL2 as an antibody target. Whether an autoantibody or antibody against NAALADL2 could matter depends on whether native NAALADL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NAALADL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NAALADL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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