Seroatlas · Human Serome Atlas

NAALADL1

Aminopeptidase NAALADL1

Also known as: HILAP, NALDL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UQQ1
Gene
NAALADL1
Ensembl
ENSG00000168060
Chromosome
11
Canonical length
740 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables aminopeptidase activity; metal ion binding activity; and protein homodimerization activity. Involved in peptide catabolic process. Predicted to be located in apical plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

740 residues, UniProt reviewed canonical sequence.

>Q9UQQ1|NAALADL1
     1  MQWTKVLGLG LGAAALLGLG IILGHFAIPK KANSLAPQDL DLEILETVMG QLDAHRIREN
    61  LRELSREPHL ASSPRDEDLV QLLLQRWKDP ESGLDSAEAS TYEVLLSFPS QEQPNVVDIV
   121  GPTGGIIHSC HRTEENVTGE QGGPDVVQPY AAYAPSGTPQ GLLVYANRGA EEDFKELQTQ
   181  GIKLEGTIAL TRYGGVGRGA KAVNAAKHGV AGVLVYTDPA DINDGLSSPD ETFPNSWYLP
   241  PSGVERGSYY EYFGDPLTPY LPAVPSSFRV DLANVSGFPP IPTQPIGFQD ARDLLCNLNG
   301  TLAPATWQGA LGCHYRLGPG FRPDGDFPAD SQVNVSVYNR LELRNSSNVL GIIRGAVEPD
   361  RYVLYGNHRD SWVHGAVDPS SGTAVLLELS RVLGTLLKKG TWRPRRSIVF ASWGAEEFGL
   421  IGSTEFTEEF FNKLQERTVA YINVDISVFA NATLRVQGTP PVQSVVFSAT KEIRSPGPGD
   481  LSIYDNWIRY FNRSSPVYGL VPSLGSLGAG SDYAPFVHFL GISSMDIAYT YDRSKTSARI
   541  YPTYHTAFDT FDYVDKFLDP GFSSHQAVAR TAGSVILRLS DSFFLPLKVS DYSETLRSFL
   601  QAAQQDLGAL LEQHSISLGP LVTAVEKFEA EAAALGQRIS TLQKGSPDPL QVRMLNDQLM
   661  LLERTFLNPR AFPEERYYSH VLWAPRTGSV VTFPGLSNAC SRARDTASGS EAWAEVQRQL
   721  SIVVTALEGA AATLRPVADL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NAALADL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.22
Highest tissue expression
96 nTPM

Expression across tissuesHPA

Tissue

  • small intestine: 96 nTPM
  • cervix: 22 nTPM
  • ovary: 22 nTPM
  • blood vessel: 22 nTPM
  • bone marrow: 20 nTPM
  • duodenum: 19 nTPM

Single-cell type

  • enterocytes: 610 nCPM
  • breast myoepithelial cells: 25 nCPM
  • enteric transient amplifying cells: 24 nCPM
  • tuft cells: 23 nCPM
  • ovarian stromal cells: 23 nCPM
  • colonocytes: 21 nCPM

Immune cell

  • basophil: 183 nTPM
  • NK-cell: 80 nTPM
  • T-reg: 45 nTPM
  • eosinophil: 36 nTPM
  • naive B-cell: 30 nTPM
  • gdT-cell: 30 nTPM

Brain region

  • choroid plexus: 8.2 nTPM
  • cerebellum: 3.3 nTPM
  • pons: 3.3 nTPM
  • medulla oblongata: 3.2 nTPM
  • spinal cord: 3.1 nTPM
  • amygdala: 2.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NAALADL1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 167 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.2
gnomAD pLI
0
gnomAD missense Z
0.17
DepMap mean gene effect
-0.21
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NAALADL1 as an antibody target. Whether an autoantibody or antibody against NAALADL1 could matter depends on whether native NAALADL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NAALADL1 is annotated at the cell surface, where native NAALADL1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NAALADL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NAALADL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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