Seroatlas · Human Serome Atlas

PARP11

Protein mono-ADP-ribosyltransferase PARP11

Also known as: ARTD11, C12orf6, PAR11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NR21
Gene: PARP11
Ensembl: ENSG00000111224
Chromosome: 12
Canonical length: 338 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

Enables NAD+ poly-ADP-ribosyltransferase activity and NAD+-protein mono-ADP-ribosyltransferase activity. Involved in protein auto-ADP-ribosylation. Located in cytosol; nuclear body; and nuclear envelope. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

338 residues, UniProt reviewed canonical sequence.

>Q9NR21|PARP11
     1  MWEANPEMFH KAEELFSKTT NNEVDDMDTS DTQWGWFYLA ECGKWHMFQP DTNSQCSVSS
    61  EDIEKSFKTN PCGSISFTTS KFSYKIDFAE MKQMNLTTGK QRLIKRAPFS ISAFSYICEN
   121  EAIPMPPHWE NVNTQVPYQL IPLHNQTHEY NEVANLFGKT MDRNRIKRIQ RIQNLDLWEF
   181  FCRKKAQLKK KRGVPQINEQ MLFHGTSSEF VEAICIHNFD WRINGIHGAV FGKGTYFARD
   241  AAYSSRFCKD DIKHGNTFQI HGVSLQQRHL FRTYKSMFLA RVLIGDYING DSKYMRPPSK
   301  DGSYVNLYDS CVDDTWNPKI FVVFDANQIY PEYLIDFH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PARP11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 9.6 nTPM

Expression across tissuesHPA

Tissue

thymus: 9.6 nTPM
lymph node: 9.5 nTPM
tonsil: 8.8 nTPM
testis: 8.7 nTPM
thyroid gland: 8.5 nTPM
prostate: 8.1 nTPM

Single-cell type

sertoli cells: 136 nCPM
early spermatids: 99 nCPM
pituitary stem cells: 89 nCPM
thymocytes: 76 nCPM
prostatic glandular cells: 73 nCPM
hematopoietic stem cells: 71 nCPM

Immune cell

basophil: 21 nTPM
MAIT T-cell: 10 nTPM
memory B-cell: 10 nTPM
naive CD4 T-cell: 9.3 nTPM
eosinophil: 9.2 nTPM
myeloid DC: 9 nTPM

Brain region

white matter: 11 nTPM
hypothalamus: 11 nTPM
medulla oblongata: 11 nTPM
midbrain: 11 nTPM
pons: 10 nTPM
basal ganglia: 9.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.19
gnomAD pLI: 0
gnomAD missense Z: 0.7
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PARP11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PARP12

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PARP11 as an antibody target. Whether an autoantibody or antibody against PARP11 could matter depends on whether native PARP11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PARP11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PARP11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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