Seroatlas · Human Serome Atlas

TIPARP

Protein mono-ADP-ribosyltransferase TIPARP

Also known as: ARTD14, DDF1, DKFZP434J214, DKFZp686N0351, PARP-1, PARP-7, PARP7, PARPT_HUMAN, pART14, RM1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z3E1
Gene: TIPARP
Ensembl: ENSG00000163659
Chromosome: 3
Canonical length: 657 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Microtubules

OverviewNCBI Gene

This gene encodes a member of the poly(ADP-ribose) polymerase superfamily. Studies of the mouse ortholog have shown that the encoded protein catalyzes histone poly(ADP-ribosyl)ation and may be involved in T-cell function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

657 residues, UniProt reviewed canonical sequence.

>Q7Z3E1|TIPARP
     1  MEMETTEPEP DCVVQPPSPP DDFSCQMRLS EKITPLKTCF KKKDQKRLGT GTLRSLRPIL
    61  NTLLESGSLD GVFRSRNQST DENSLHEPMM KKAMEINSSC PPAENNMSVL IPDRTNVGDQ
   121  IPEAHPSTEA PERVVPIQDH SFPSETLSGT VADSTPAHFQ TDLLHPVSSD VPTSPDCLDK
   181  VIDYVPGIFQ ENSFTIQYIL DTSDKLSTEL FQDKSEEASL DLVFELVNQL QYHTHQENGI
   241  EICMDFLQGT CIYGRDCLKH HTVLPYHWQI KRTTTQKWQS VFNDSQEHLE RFYCNPENDR
   301  MRMKYGGQEF WADLNAMNVY ETTEFDQLRR LSTPPSSNVN SIYHTVWKFF CRDHFGWREY
   361  PESVIRLIEE ANSRGLKEVR FMMWNNHYIL HNSFFRREIK RRPLFRSCFI LLPYLQTLGG
   421  VPTQAPPPLE ATSSSQIICP DGVTSANFYP ETWVYMHPSQ DFIQVPVSAE DKSYRIIYNL
   481  FHKTVPEFKY RILQILRVQN QFLWEKYKRK KEYMNRKMFG RDRIINERHL FHGTSQDVVD
   541  GICKHNFDPR VCGKHATMFG QGSYFAKKAS YSHNFSKKSS KGVHFMFLAK VLTGRYTMGS
   601  HGMRRPPPVN PGSVTSDLYD SCVDNFFEPQ IFVIFNDDQS YPYFVIQYEE VSNTVSI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TIPARP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 93 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 93 nTPM
bone marrow: 70 nTPM
adipose tissue: 63 nTPM
urinary bladder: 61 nTPM
adrenal gland: 53 nTPM
esophagus: 52 nTPM

Single-cell type

urothelial cells: 532 nCPM
endometrial secretory cells: 425 nCPM
innate lymphoid cells: 390 nCPM
esophageal apical cells: 380 nCPM
early spermatids: 368 nCPM
ocular epithelial cells: 363 nCPM

Immune cell

basophil: 54 nTPM
neutrophil: 16 nTPM
NK-cell: 12 nTPM
non-classical monocyte: 9.3 nTPM
MAIT T-cell: 8.6 nTPM
memory CD8 T-cell: 8.2 nTPM

Brain region

medulla oblongata: 60 nTPM
midbrain: 47 nTPM
thalamus: 44 nTPM
cerebral cortex: 35 nTPM
hypothalamus: 33 nTPM
white matter: 33 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TIPARP.

Disease | ImmuneIEDB

Conditions an epitope on TIPARP was assayed in.

psoriasis T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.11
gnomAD pLI: 1
gnomAD missense Z: 1.73
DepMap mean gene effect: -0.35
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TIPARP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TIPARP as an antibody target. Whether an autoantibody or antibody against TIPARP could matter depends on whether native TIPARP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TIPARP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TIPARP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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