Seroatlas · Human Serome Atlas

DTX4

E3 ubiquitin-protein ligase DTX4

Also known as: DTX4_HUMAN, KIAA0937, RNF155

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y2E6
Gene: DTX4
Ensembl: ENSG00000110042
Chromosome: 11
Canonical length: 619 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Enables ubiquitin protein ligase activity. Involved in negative regulation of innate immune response; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein K48-linked ubiquitination. Is active in centrosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

619 residues, UniProt reviewed canonical sequence.

>Q9Y2E6|DTX4
     1  MLLASAVVVW EWLNEHGRWR PYSPAVSHHI EAVVRAGPRA GGSVVLGQVD SRLAPYIIDL
    61  QSMNQFRQDT GTLRPVRRNY YDPSSAPGKG VVWEWENDNG SWTPYDMEVG ITIQHAYEKQ
   121  HPWIDLTSIG FSYVIDFNTM GQINRQTQRQ RRVRRRLDLI YPMVTGTLPK AQSWPVSPGP
   181  ATSPPMSPCS CPQCVLVMSV KAAVVNGSTG PLQLPVTRKN MPPPGVVKLP PLPGSGAKPL
   241  DSTGTIRGPL KTAPSQVIRR QASSMPTGTT MGSPASPPGP NSKTGRVALA TLNRTNLQRL
   301  AIAQSRVLIA SGVPTVPVKN LNGSSPVNPA LAGITGILMS AAGLPVCLTR PPKLVLHPPP
   361  VSKSEIKSIP GVSNTSRKTT KKQAKKGKTP EEVLKKYLQK VRHPPDEDCT ICMERLTAPS
   421  GYKGPQPTVK PDLVGKLSRC GHVYHIYCLV AMYNNGNKDG SLQCPTCKTI YGVKTGTQPP
   481  GKMEYHLIPH SLPGHPDCKT IRIIYSIPPG IQGPEHPNPG KSFSARGFPR HCYLPDSEKG
   541  RKVLKLLLVA WDRRLIFAIG TSSTTGESDT VIWNEVHHKT EFGSNLTGHG YPDANYLDNV
   601  LAELAAQGIS EDSTAQEKD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DTX4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 56 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 56 nTPM
liver: 30 nTPM
salivary gland: 20 nTPM
midbrain: 18 nTPM
cerebellum: 16 nTPM
lung: 16 nTPM

Single-cell type

alveolar cells type 1: 62 nCPM
oligodendrocytes: 49 nCPM
prostatic hillock cells: 43 nCPM
lacrimal acinar cells: 43 nCPM
papillary tip epithelial cells: 40 nCPM
conjunctival goblet cells: 40 nCPM

Immune cell

plasmacytoid DC: 2.8 nTPM
neutrophil: 1.5 nTPM
naive B-cell: 1.3 nTPM
memory B-cell: 1 nTPM
basophil: 0.7 nTPM
myeloid DC: 0.6 nTPM

Brain region

white matter: 105 nTPM
spinal cord: 71 nTPM
medulla oblongata: 65 nTPM
pons: 58 nTPM
thalamus: 54 nTPM
midbrain: 48 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.48
gnomAD pLI: 0.22
gnomAD missense Z: 1.67
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DTX4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

NLRP4

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DTX4 as an antibody target. Whether an autoantibody or antibody against DTX4 could matter depends on whether native DTX4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DTX4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DTX4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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