PARP14

Protein identityUniProt · HPA

UniProt accession

Q460N5

Gene

PARP14

Ensembl

ENSG00000173193

Chromosome

3

Canonical length

1801 aa

Protein class

Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Subcellular location

Cytosol

OverviewNCBI Gene

This gene encodes a member of the poly(ADP-ribose) polymerase (PARP) protein family. The encoded anti-apoptotic protein may regulate aerobic glycolysis and promote survival of cancer cells. Increased expression of this gene has been reported in a variety of tumor types. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

1801 residues, UniProt reviewed canonical sequence.

>Q460N5|PARP14
     1  MAVPGSFPLL VEGSWGPDPP KNLNTKLQMY FQSPKRSGGG ECEVRQDPRS PSRFLVFFYP
    61  EDVRQKVLER KNHELVWQGK GTFKLTVQLP ATPDEIDHVF EEELLTKESK TKEDVKEPDV
   121  SEELDTKLPL DGGLDKMEDI PEECENISSL VAFENLKANV TDIMLILLVE NISGLSNDDF
   181  QVEIIRDFDV AVVTFQKHID TIRFVDDCTK HHSIKQLQLS PRLLEVTNTI RVENLPPGAD
   241  DYSLKLFFEN PYNGGGRVAN VEYFPEESSA LIEFFDRKVL DTIMATKLDF NKMPLSVFPY
   301  YASLGTALYG KEKPLIKLPA PFEESLDLPL WKFLQKKNHL IEEINDEMRR CHCELTWSQL
   361  SGKVTIRPAA TLVNEGRPRI KTWQADTSTT LSSIRSKYKV NPIKVDPTMW DTIKNDVKDD
   421  RILIEFDTLK EMVILAGKSE DVQSIEVQVR ELIESTTQKI KREEQSLKEK MIISPGRYFL
   481  LCHSSLLDHL LTECPEIEIC YDRVTQHLCL KGPSADVYKA KCEIQEKVYT MAQKNIQVSP
   541  EIFQFLQQVN WKEFSKCLFI AQKILALYEL EGTTVLLTSC SSEALLEAEK QMLSALNYKR
   601  IEVENKEVLH GKKWKGLTHN LLKKQNSSPN TVIINELTSE TTAEVIITGC VKEVNETYKL
   661  LFNFVEQNMK IERLVEVKPS LVIDYLKTEK KLFWPKIKKV NVQVSFNPEN KQKGILLTGS
   721  KTEVLKAVDI VKQVWDSVCV KSVHTDKPGA KQFFQDKARF YQSEIKRLFG CYIELQENEV
   781  MKEGGSPAGQ KCFSRTVLAP GVVLIVQQGD LARLPVDVVV NASNEDLKHY GGLAAALSKA
   841  AGPELQADCD QIVKREGRLL PGNATISKAG KLPYHHVIHA VGPRWSGYEA PRCVYLLRRA
   901  VQLSLCLAEK YKYRSIAIPA ISSGVFGFPL GRCVETIVSA IKENFQFKKD GHCLKEIYLV
   961  DVSEKTVEAF AEAVKTVFKA TLPDTAAPPG LPPAAAGPGK TSWEKGSLVS PGGLQMLLVK
  1021  EGVQNAKTDV VVNSVPLDLV LSRGPLSKSL LEKAGPELQE ELDTVGQGVA VSMGTVLKTS
  1081  SWNLDCRYVL HVVAPEWRNG STSSLKIMED IIRECMEITE SLSLKSIAFP AIGTGNLGFP
  1141  KNIFAELIIS EVFKFSSKNQ LKTLQEVHFL LHPSDHENIQ AFSDEFARRA NGNLVSDKIP
  1201  KAKDTQGFYG TVSSPDSGVY EMKIGSIIFQ VASGDITKEE ADVIVNSTSN SFNLKAGVSK
  1261  AILECAGQNV ERECSQQAQQ RKNDYIITGG GFLRCKNIIH VIGGNDVKSS VSSVLQECEK
  1321  KNYSSICLPA IGTGNAKQHP DKVAEAIIDA IEDFVQKGSA QSVKKVKVVI FLPQVLDVFY
  1381  ANMKKREGTQ LSSQQSVMSK LASFLGFSKQ SPQKKNHLVL EKKTESATFR VCGENVTCVE
  1441  YAISWLQDLI EKEQCPYTSE DECIKDFDEK EYQELNELQK KLNINISLDH KRPLIKVLGI
  1501  SRDVMQARDE IEAMIKRVRL AKEQESRADC ISEFIEWQYN DNNTSHCFNK MTNLKLEDAR
  1561  REKKKTVDVK INHRHYTVNL NTYTATDTKG HSLSVQRLTK SKVDIPAHWS DMKQQNFCVV
  1621  ELLPSDPEYN TVASKFNQTC SHFRIEKIER IQNPDLWNSY QAKKKTMDAK NGQTMNEKQL
  1681  FHGTDAGSVP HVNRNGFNRS YAGKNAVAYG KGTYFAVNAN YSANDTYSRP DANGRKHVYY
  1741  VRVLTGIYTH GNHSLIVPPS KNPQNPTDLY DTVTDNVHHP SLFVAFYDYQ AYPEYLITFR
  1801  K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PARP14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

26 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.4

gnomAD pLI

0.01

gnomAD missense Z

2.63

DepMap mean gene effect

-0.13

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• innate immune response
• NAD+ catabolic process
• negative regulation of gene expression
• negative regulation of type II interferon-mediated signaling pathway
• negative regulation of tyrosine phosphorylation of STAT protein
• positive regulation of interleukin-4-mediated signaling pathway
• positive regulation of tyrosine phosphorylation of STAT protein
• protein poly-ADP-ribosylation

Molecular functions

• enzyme binding
• NAD+ binding
• NAD+ poly-ADP-ribosyltransferase activity
• NAD+-protein mono-ADP-ribosyltransferase activity
• NAD+-protein-glutamate ADP-ribosyltransferase activity
• nucleotidyltransferase activity
• transcription corepressor activity

Cellular components

• cytoplasm
• cytosol
• membrane
• nucleus
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Macro domain
• WWE domain
• Poly(ADP-ribose) polymerase, catalytic domain
• Nucleotide-binding alpha-beta plait domain superfamily
• WWE domain superfamily
• Macro domain-like
• Mono-ADP-ribosyltransferase ARTD/PARP
• PARP14-like, eighth type I KH domain
• PAR14-like, first RRM domain
• Poly(ADP-ribose) polymerase catalytic domain
• Macro domain
• PARP14, third RRM domain
• PAR14-like, first RRM domain
• PARP14-like, eighth type I KH domain
• PARP-14, RNA recognition motif 2
• Mono-ADP-ribosyltransferase PARP14, WWE domain
• PARP14, second type I KH domain
• PARP14, first type I KH domain
• PARP14, third type I KH domain
• PARP14, fourth type I KH domain
• PARP14, fifth type I KH domain
• PARP14, sixth type I KH domain
• PARP14, second RRM domain
• Parp14 WWE domain
• PARP14, first type I KH domain
• PARP14, second RRM domain
• PARP14, second type I KH domain
• PARP14, third type I KH domain
• PARP14, fourth type I KH domain
• PARP14, fifth type I KH domain
• PARP14, sixth type I KH domain

KeywordsUniProt

• ADP-ribosylation
• Cytoplasm
• Glycosyltransferase
• Immunity
• Innate immunity
• NAD
• Nucleotidyltransferase
• Nucleus
• Phosphoprotein
• Repeat
• Transcription
• Transcription regulation
• Transferase

InteractionsUniProt · HPA

Protein binding partners of PARP14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PARP10
• PARP9
• STAT6