Seroatlas · Human Serome Atlas

METAP1D

Methionine aminopeptidase 1D, mitochondrial

Also known as: MAP12_HUMAN, MAP1D, Metap1l

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UB28
Gene: METAP1D
Ensembl: ENSG00000172878
Chromosome: 2
Canonical length: 335 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

The N-terminal methionine excision pathway is an essential process in which the N-terminal methionine is removed from many proteins, thus facilitating subsequent protein modification. In mitochondria, enzymes that catalyze this reaction are celled methionine aminopeptidases (MetAps, or MAPs; EC 3.4.11.18) (Serero et al., 2003 [PubMed 14532271]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

335 residues, UniProt reviewed canonical sequence.

>Q6UB28|METAP1D
     1  MAAPSGVHLL VRRGSHRIFS SPLNHIYLHK QSSSQQRRNF FFRRQRDISH SIVLPAAVSS
    61  AHPVPKHIKK PDYVTTGIVP DWGDSIEVKN EDQIQGLHQA CQLARHVLLL AGKSLKVDMT
   121  TEEIDALVHR EIISHNAYPS PLGYGGFPKS VCTSVNNVLC HGIPDSRPLQ DGDIINIDVT
   181  VYYNGYHGDT SETFLVGNVD ECGKKLVEVA RRCRDEAIAA CRAGAPFSVI GNTISHITHQ
   241  NGFQVCPHFV GHGIGSYFHG HPEIWHHAND SDLPMEEGMA FTIEPIITEG SPEFKVLEDA
   301  WTVVSLDNQR SAQFEHTVLI TSRGAQILTK LPHEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against METAP1D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

ovary: 13 nTPM
pancreas: 8.8 nTPM
skeletal muscle: 8.3 nTPM
fallopian tube: 7 nTPM
liver: 6.4 nTPM
spleen: 6.4 nTPM

Single-cell type

myonuclei: 108 nCPM
leydig cells: 89 nCPM
megakaryocyte-erythroid progenitors: 67 nCPM
ovarian stromal cells: 64 nCPM
oligodendrocyte progenitor cells: 60 nCPM
peritubular myoid cells: 58 nCPM

Immune cell

naive CD8 T-cell: 1.1 nTPM
naive B-cell: 0.7 nTPM
memory CD4 T-cell: 0.5 nTPM
naive CD4 T-cell: 0.5 nTPM
gdT-cell: 0.4 nTPM
intermediate monocyte: 0.4 nTPM

Brain region

hypothalamus: 7.5 nTPM
white matter: 7 nTPM
pons: 6.5 nTPM
basal ganglia: 6.2 nTPM
cerebral cortex: 6.2 nTPM
thalamus: 5.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
gnomAD missense Z: 0.64
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

mitochondrion

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads METAP1D as an antibody target. Whether an autoantibody or antibody against METAP1D could matter depends on whether native METAP1D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

METAP1D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label METAP1D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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