Seroatlas · Human Serome Atlas

METAP1

Methionine aminopeptidase 1

Also known as: KIAA0094, MAP11_HUMAN, MAP1A, MetAP1A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P53582
Gene
METAP1
Ensembl
ENSG00000164024
Chromosome
4
Canonical length
386 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Enables aminopeptidase activity. Involved in protein maturation. Predicted to be located in cytoplasm. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

386 residues, UniProt reviewed canonical sequence.

>P53582|METAP1
     1  MAAVETRVCE TDGCSSEAKL QCPTCIKLGI QGSYFCSQEC FKGSWATHKL LHKKAKDEKA
    61  KREVSSWTVE GDINTDPWAG YRYTGKLRPH YPLMPTRPVP SYIQRPDYAD HPLGMSESEQ
   121  ALKGTSQIKL LSSEDIEGMR LVCRLAREVL DVAAGMIKPG VTTEEIDHAV HLACIARNCY
   181  PSPLNYYNFP KSCCTSVNEV ICHGIPDRRP LQEGDIVNVD ITLYRNGYHG DLNETFFVGE
   241  VDDGARKLVQ TTYECLMQAI DAVKPGVRYR ELGNIIQKHA QANGFSVVRS YCGHGIHKLF
   301  HTAPNVPHYA KNKAVGVMKS GHVFTIEPMI CEGGWQDETW PDGWTAVTRD GKRSAQFEHT
   361  LLVTDTGCEI LTRRLDSARP HFMSQF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against METAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
51 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 51 nTPM
  • testis: 50 nTPM
  • epididymis: 41 nTPM
  • thymus: 39 nTPM
  • heart muscle: 39 nTPM
  • blood vessel: 37 nTPM

Single-cell type

  • late spermatids: 3,048 nCPM
  • early spermatids: 434 nCPM
  • cardiomyocytes: 122 nCPM
  • esophageal apical cells: 121 nCPM
  • prostatic hillock cells: 110 nCPM
  • endometrial luminal cells: 110 nCPM

Immune cell

  • MAIT T-cell: 23 nTPM
  • basophil: 19 nTPM
  • memory CD4 T-cell: 18 nTPM
  • T-reg: 18 nTPM
  • gdT-cell: 18 nTPM
  • NK-cell: 18 nTPM

Brain region

  • basal ganglia: 18 nTPM
  • cerebral cortex: 18 nTPM
  • hypothalamus: 16 nTPM
  • cerebellum: 16 nTPM
  • white matter: 16 nTPM
  • hippocampal formation: 15 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about METAP1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 50 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.53
gnomAD pLI
0.11
gnomAD missense Z
1.87
DepMap mean gene effect
-0.75
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of METAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads METAP1 as an antibody target. Whether an autoantibody or antibody against METAP1 could matter depends on whether native METAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

METAP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label METAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/METAP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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