Seroatlas · Human Serome Atlas

XPNPEP2

Xaa-Pro aminopeptidase 2

Also known as: XPP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43895
Gene: XPNPEP2
Ensembl: ENSG00000122121
Chromosome: X
Canonical length: 674 aa
Protein class: Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol
Secretome location: Intracellular and membrane
Quaternary structure: Homotrimer

OverviewNCBI Gene

Aminopeptidase P is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. Structurally, the enzyme is a member of the 'pita bread fold' family and occurs in mammalian tissues in both soluble and GPI-anchored membrane-bound forms. A membrane-bound and soluble form of this enzyme have been identified as products of two separate genes. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

674 residues, UniProt reviewed canonical sequence.

>O43895|XPNPEP2
     1  MARAHWGCCP WLVLLCACAW GHTKPVDLGG QDVRNCSTNP PYLPVTVVNT TMSLTALRQQ
    61  MQTQNLSAYI IPGTDAHMNE YIGQHDERRA WITGFTGSAG TAVVTMKKAA VWTDSRYWTQ
   121  AERQMDCNWE LHKEVGTTPI VTWLLTEIPA GGRVGFDPFL LSIDTWESYD LALQGSNRQL
   181  VSITTNLVDL VWGSERPPVP NQPIYALQEA FTGSTWQEKV SGVRSQMQKH QKVPTAVLLS
   241  ALEETAWLFN LRASDIPYNP FFYSYTLLTD SSIRLFANKS RFSSETLSYL NSSCTGPMCV
   301  QIEDYSQVRD SIQAYSLGDV RIWIGTSYTM YGIYEMIPKE KLVTDTYSPV MMTKAVKNSK
   361  EQALLKASHV RDAVAVIRYL VWLEKNVPKG TVDEFSGAEI VDKFRGEEQF SSGPSFETIS
   421  ASGLNAALAH YSPTKELNRK LSSDEMYLLD SGGQYWDGTT DITRTVHWGT PSAFQKEAYT
   481  RVLIGNIDLS RLIFPAATSG RMVEAFARRA LWDAGLNYGH GTGHGIGNFL CVHEWPVGFQ
   541  SNNIAMAKGM FTSIEPGYYK DGEFGIRLED VALVVEAKTK YPGSYLTFEV VSFVPYDRNL
   601  IDVSLLSPEH LQYLNRYYQT IREKVGPELQ RRQLLEEFEW LQQHTEPLAA RAPDTASWAS
   661  VLVVSTLAIL GWSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against XPNPEP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 157 nTPM

Expression across tissuesHPA

Tissue

small intestine: 157 nTPM
kidney: 146 nTPM
duodenum: 93 nTPM
liver: 22 nTPM
urinary bladder: 7.9 nTPM
adipose tissue: 7.2 nTPM

Single-cell type

enterocytes: 498 nCPM
proximal tubule cells: 75 nCPM
hepatocytes: 22 nCPM
fibroblasts: 18 nCPM
goblet cells: 16 nCPM
enteric transient amplifying cells: 16 nCPM

Immune cell

gdT-cell: 4.3 nTPM
memory CD8 T-cell: 2.8 nTPM
non-classical monocyte: 2.8 nTPM
naive CD8 T-cell: 2 nTPM
intermediate monocyte: 1.4 nTPM
T-reg: 1.4 nTPM

Brain region

medulla oblongata: 0.3 nTPM
amygdala: 0.2 nTPM
basal ganglia: 0.1 nTPM
cerebellum: 0.1 nTPM
cerebral cortex: 0.1 nTPM
choroid plexus: 0.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about XPNPEP2.

Disease | AllUniProt

Conditions XPNPEP2 is implicated in, by any mechanism.

Angioedema induced by ACE inhibitors (AEACEI) MIM:300909

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
gnomAD missense Z: -0.34
DepMap mean gene effect: 0.22
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteolysis

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads XPNPEP2 as an antibody target. Whether an autoantibody or antibody against XPNPEP2 could matter depends on whether native XPNPEP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

XPNPEP2 is annotated at the cell surface, where native XPNPEP2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label XPNPEP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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