Tim10-like domain superfamily

Definition

This domain superfamily is found in mitochondrial import inner membrane translocase subunits Tim8, Tim9, Tim10 and Tim13, which are located in the mitochondrial intermembrane space. The Tim8-Tim13 complex has a complex architecture, similar to the Tim9-Tim10 complex, composed of a hexametric architecture with long helices which look like tentacles extend from a central loop PMID:18706423. In each subunit of the Tim9-Tim10 complex, a signature "twin CX3C" motif forms two intramolecular disulfides PMID:16387659. Tim9 plays an important functional role that includes facilitating the initial steps in translocating precursor substrates into the intermembrane space PMID:19037098.

6 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (6 proteins: gene, accession, name)

• TIMM10
• TIMM10B
• TIMM13
• TIMM8A
• TIMM8B
• TIMM9