Seroatlas · Human Serome Atlas

TIMM8B

Mitochondrial import inner membrane translocase subunit Tim8 B

Also known as: DDP2, FLJ21744, MGC102866, MGC117373, TIM8B, TIM8B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y5J9
Gene: TIMM8B
Ensembl: ENSG00000150779
Chromosome: 11
Canonical length: 83 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of a well-conserved family of proteins with similarity to yeast Tim mitochondrial import proteins. This gene is encoded by a nuclear gene and is transported into the intermembrane space of the mitochondrion. When formed into complexes, these proteins guide membrane-spanning proteins across the mitochondrial intermembrane space before they are added into the mitochondrial inner membrane. This gene is adjacent to succinate dehydrogenase, subunit D (SDHD), in which mutations have been found in affected members of families with hereditary paraganglioma.[provided by RefSeq, Aug 2009]

Canonical amino-acid sequenceUniProt

83 residues, UniProt reviewed canonical sequence.

>Q9Y5J9|TIMM8B
     1  MAELGEADEA ELQRLVAAEQ QKAQFTAQVH HFMELCWDKC VEKPGNRLDS RTENCLSSCV
    61  DRFIDTTLAI TSRFAQIVQK GGQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TIMM8B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 137 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 137 nTPM
skeletal muscle: 100 nTPM
tongue: 91 nTPM
esophagus: 66 nTPM
adrenal gland: 56 nTPM
liver: 51 nTPM

Single-cell type

esophageal suprabasal cells: 761 nCPM
esophageal apical cells: 704 nCPM
hepatocytes: 518 nCPM
esophageal basal cells: 412 nCPM
hofbauer cells: 376 nCPM
megakaryocytes: 328 nCPM

Immune cell

plasmacytoid DC: 214 nTPM
eosinophil: 158 nTPM
myeloid DC: 158 nTPM
intermediate monocyte: 157 nTPM
classical monocyte: 147 nTPM
non-classical monocyte: 134 nTPM

Brain region

cerebellum: 18 nTPM
thalamus: 16 nTPM
white matter: 16 nTPM
choroid plexus: 16 nTPM
hypothalamus: 16 nTPM
medulla oblongata: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.8
gnomAD pLI: 0.01
gnomAD missense Z: -0.58
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TIMM8B as an antibody target. Whether an autoantibody or antibody against TIMM8B could matter depends on whether native TIMM8B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TIMM8B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TIMM8B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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