Seroatlas · Human Serome Atlas

TIMM10

Mitochondrial import inner membrane translocase subunit Tim10

Also known as: TIM10, TIM10_HUMAN, TIM10A, TIMM10A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P62072
Gene: TIMM10
Ensembl: ENSG00000134809
Chromosome: 11
Canonical length: 90 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

The mitochondrial protein encoded by this gene belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane, functioning as intermembrane space chaperones for the highly insoluble carrier proteins. [provided by RefSeq, Nov 2011]

Canonical amino-acid sequenceUniProt

90 residues, UniProt reviewed canonical sequence.

>P62072|TIMM10
     1  MDPLRAQQLA AELEVEMMAD MYNRMTSACH RKCVPPHYKE AELSKGESVC LDRCVSKYLD
    61  IHERMGKKLT ELSMQDEELM KRVQQSSGPA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TIMM10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 76 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 76 nTPM
liver: 75 nTPM
tongue: 63 nTPM
choroid plexus: 61 nTPM
cerebral cortex: 59 nTPM
heart muscle: 59 nTPM

Single-cell type

late spermatids: 389 nCPM
hepatocytes: 232 nCPM
esophageal basal cells: 158 nCPM
epididymal principal cells: 153 nCPM
hofbauer cells: 145 nCPM
early spermatids: 142 nCPM

Immune cell

memory B-cell: 189 nTPM
naive B-cell: 180 nTPM
plasmacytoid DC: 147 nTPM
myeloid DC: 147 nTPM
total PBMC: 146 nTPM
naive CD4 T-cell: 119 nTPM

Brain region

spinal cord: 34 nTPM
white matter: 32 nTPM
hypothalamus: 32 nTPM
cerebral cortex: 31 nTPM
basal ganglia: 30 nTPM
cerebellum: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.85
gnomAD pLI: 0
gnomAD missense Z: 0.92
DepMap mean gene effect: -1.14
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TIMM10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TIMM10 as an antibody target. Whether an autoantibody or antibody against TIMM10 could matter depends on whether native TIMM10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TIMM10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TIMM10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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