Seroatlas · Human Serome Atlas

TIMM9

Mitochondrial import inner membrane translocase subunit Tim9

Also known as: TIM9_HUMAN, TIM9A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y5J7
Gene: TIMM9
Ensembl: ENSG00000100575
Chromosome: 14
Canonical length: 89 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

TIMM9 belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane.[supplied by OMIM, Apr 2004]

Canonical amino-acid sequenceUniProt

89 residues, UniProt reviewed canonical sequence.

>Q9Y5J7|TIMM9
     1  MAAQIPESDQ IKQFKEFLGT YNKLTETCFL DCVKDFTTRE VKPEETTCSE HCLQKYLKMT
    61  QRISMRFQEY HIQQNEALAA KAGLLGQPR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TIMM9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 68 nTPM

Expression across tissuesHPA

Tissue

pancreas: 68 nTPM
skeletal muscle: 61 nTPM
ovary: 46 nTPM
colon: 41 nTPM
kidney: 40 nTPM
adipose tissue: 39 nTPM

Single-cell type

late primary spermatocytes: 141 nCPM
esophageal basal cells: 128 nCPM
decidual stromal cells: 122 nCPM
oocytes: 115 nCPM
migrating cytotrophoblasts: 113 nCPM
extravillous trophoblasts: 110 nCPM

Immune cell

memory B-cell: 29 nTPM
naive CD4 T-cell: 29 nTPM
NK-cell: 28 nTPM
naive CD8 T-cell: 27 nTPM
MAIT T-cell: 26 nTPM
T-reg: 25 nTPM

Brain region

white matter: 34 nTPM
cerebellum: 33 nTPM
choroid plexus: 30 nTPM
basal ganglia: 29 nTPM
hypothalamus: 28 nTPM
midbrain: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.46
gnomAD pLI: 0.02
gnomAD missense Z: 0.64
DepMap mean gene effect: -0.53
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TIMM9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TIMM9 as an antibody target. Whether an autoantibody or antibody against TIMM9 could matter depends on whether native TIMM9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TIMM9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TIMM9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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