TIMM13

Protein identityUniProt · HPA

UniProt accession

Q9Y5L4

Gene

TIMM13

Ensembl

ENSG00000099800

Chromosome

19

Canonical length

95 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoli fibrillar center,Mitochondria

OverviewNCBI Gene

This gene encodes a member of the evolutionarily conserved TIMM (translocase of inner mitochondrial membrane) family of proteins that function as chaperones in the import of proteins from the cytoplasm into the mitochondrial inner membrane. Proteins of this family play a role in collecting substrate proteins from the translocase of the outer mitochondrial membrane (TOM) complex and delivering them to either the sorting and assembly machinery in the outer mitochondrial membrane (SAM) complex or the TIMM22 complex in the inner mitochondrial membrane. The encoded protein and the translocase of mitochondrial inner membrane 8a protein form a 70 kDa complex in the intermembrane space. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

95 residues, UniProt reviewed canonical sequence.

>Q9Y5L4|TIMM13
     1  MEGGFGSDFG GSGSGKLDPG LIMEQVKVQI AVANAQELLQ RMTDKCFRKC IGKPGGSLDN
    61  SEQKCIAMCM DRYMDAWNTV SRAYNSRLQR ERANM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TIMM13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.51

Highest tissue expression

143 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.55

gnomAD pLI

0.06

gnomAD missense Z

-0.35

DepMap mean gene effect

-0.85

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• protein insertion into mitochondrial inner membrane
• protein targeting to mitochondrion
• protein transport
• sensory perception of sound

Molecular functions

• zinc ion binding

Cellular components

• fibrillar center
• mitochondrial inner membrane
• mitochondrial intermembrane space
• mitochondrial intermembrane space chaperone complex
• mitochondrion

Protein domainsUniProt · Pfam · InterPro

• Tim10-like
• Tim10-like domain superfamily
• Tim10/DDP family zinc finger

KeywordsUniProt

• Acetylation
• Chaperone
• Disulfide bond
• Membrane
• Metal-binding
• Mitochondrion
• Mitochondrion inner membrane
• Phosphoprotein
• Protein transport
• Translocation
• Transport
• Zinc

InteractionsUniProt · HPA

Protein binding partners of TIMM13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TIMM8A