TIMM10B
Mitochondrial import inner membrane translocase subunit Tim10 B
Also known as: FXC1, T10B_HUMAN, TIM10B, Tim9b
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9Y5J6
- Gene
- TIMM10B
- Ensembl
- ENSG00000132286
- Chromosome
- 11
- Canonical length
- 103 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
FXC1, or TIMM10B, belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane.[supplied by OMIM, Apr 2004]
Canonical amino-acid sequenceUniProt
103 residues, UniProt reviewed canonical sequence.
>Q9Y5J6|TIMM10B
1 MERQQQQQQQ LRNLRDFLLV YNRMTELCFQ RCVPSLHHRA LDAEEEACLH SCAGKLIHSN
61 HRLMAAYVQL MPALVQRRIA DYEAASAVPG VAAEQPGVSP SGSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TIMM10B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.51
- Highest tissue expression
- 27 nTPM
Expression across tissuesHPA
Tissue
- parathyroid gland: 27 nTPM
- thyroid gland: 25 nTPM
- kidney: 25 nTPM
- adrenal gland: 24 nTPM
- pancreas: 23 nTPM
- blood vessel: 23 nTPM
Single-cell type
- early primary spermatocytes: 5.2 nCPM
- early spermatids: 3.5 nCPM
- late primary spermatocytes: 3.2 nCPM
- gastric progenitor cells: 2.6 nCPM
- syncytiotrophoblasts: 2.6 nCPM
- differentiating spermatogonia: 2.5 nCPM
Immune cell
- naive CD4 T-cell: 45 nTPM
- naive CD8 T-cell: 40 nTPM
- total PBMC: 40 nTPM
- MAIT T-cell: 39 nTPM
- naive B-cell: 38 nTPM
- gdT-cell: 37 nTPM
Brain region
- pons: 47 nTPM
- midbrain: 46 nTPM
- medulla oblongata: 44 nTPM
- cerebral cortex: 42 nTPM
- white matter: 41 nTPM
- hypothalamus: 41 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.92
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.49
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of TIMM10B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TIMM10B as an antibody target. Whether an autoantibody or antibody against TIMM10B could matter depends on whether native TIMM10B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TIMM10B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TIMM10B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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