Seroatlas · Human Serome Atlas

AP3M2

AP-3 complex subunit mu-2

Also known as: AP3M2_HUMAN, AP47B, CLA20

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P53677
Gene: AP3M2
Ensembl: ENSG00000070718
Chromosome: 8
Canonical length: 418 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 3 (AP-3), which belongs to the adaptor complexes medium subunits family. The AP-3 complex plays a role in protein trafficking to lysosomes and specialized organelles. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2008]

Canonical amino-acid sequenceUniProt

418 residues, UniProt reviewed canonical sequence.

>P53677|AP3M2
     1  MIHSLFLINS SGDIFLEKHW KSVVSRSVCD YFFEAQERAT EAENVPPVIP TPHHYLLSVY
    61  RHKIFFVAVI QTEVPPLFVI EFLHRVVDTF QDYFGVCSEP VIKDNVVVVY EVLEEMLDNG
   121  FPLATESNIL KELIKPPTIL RTVVNTITGS TNVGDQLPTG QLSVVPWRRT GVKYTNNEAY
   181  FDVIEEIDAI IDKSGSTITA EIQGVIDACV KLTGMPDLTL SFMNPRLLDD VSFHPCVRFK
   241  RWESERILSF IPPDGNFRLL SYHVSAQNLV AIPVYVKHNI SFRDSSSLGR FEITVGPKQT
   301  MGKTIEGVTV TSQMPKGVLN MSLTPSQGTH TFDPVTKMLS WDVGKINPQK LPSLKGTMSL
   361  QAGASKPDEN PTINLQFKIQ QLAISGLKVN RLDMYGEKYK PFKGIKYMTK AGKFQVRT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AP3M2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

retina: 39 nTPM
cerebral cortex: 30 nTPM
hypothalamus: 25 nTPM
cerebellum: 22 nTPM
testis: 22 nTPM
parathyroid gland: 21 nTPM

Single-cell type

late spermatids: 110 nCPM
melanocytes: 104 nCPM
t-cells: 89 nCPM
differentiating spermatogonia: 82 nCPM
early spermatids: 69 nCPM
urothelial cells: 61 nCPM

Immune cell

memory CD4 T-cell: 16 nTPM
naive CD4 T-cell: 15 nTPM
MAIT T-cell: 9.7 nTPM
memory CD8 T-cell: 8.1 nTPM
NK-cell: 7.7 nTPM
gdT-cell: 7.5 nTPM

Brain region

cerebral cortex: 52 nTPM
hypothalamus: 50 nTPM
basal ganglia: 49 nTPM
pons: 44 nTPM
thalamus: 40 nTPM
midbrain: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
gnomAD missense Z: 1.39
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AP3M2 as an antibody target. Whether an autoantibody or antibody against AP3M2 could matter depends on whether native AP3M2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AP3M2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AP3M2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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