AP5M1
AP-5 complex subunit mu-1
Also known as: AP5M1_HUMAN, C14orf108, FLJ10813, mu5, MuD, MUDENG
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9H0R1
- Gene
- AP5M1
- Ensembl
- ENSG00000053770
- Chromosome
- 14
- Canonical length
- 490 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Involved in endosomal transport. Located in several cellular components, including cytosol; late endosome; and lysosome. Part of AP-type membrane coat adaptor complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
490 residues, UniProt reviewed canonical sequence.
>Q9H0R1|AP5M1
1 MAQRAVWLIS HEPGTPLCGT VRFSRRYPTV EKRARVFNGA SYVPVPEDGP FLKALLFELR
61 LLDDDKDFVE SRDSCSRINK TSIYGLLIGG EELWPVVAFL KNDMIYACVP LVEQTLSPRP
121 PLISVSGVSQ GFEFLFGIQD FLYSGQKNDS ELNTKLSQLP DLLLQACPFG TLLDANLQNS
181 LDNTNFASVT QPQKQPAWKT GTYKGKPQVS ISITEKVKSM QYDKQGIADT WQVVGTVTCK
241 CDLEGIMPNV TISLSLPTNG SPLQDILVHP CVTSLDSAIL TSSSIDAMDD SAFSGPYKFP
301 FTPPLESFNL CFYTSQVPVP PILGFYQMKE EEVQLRITIN LKLHESVKNN FEFCEAHIPF
361 YNRGPITHLE YKTSFGQLEV FREKSLLIWI IGQKFPKSME ISLSGTVTFG AKSHEKQPFD
421 PICTGETAYL KLHFRILDYT LTGCYADQHS VQVFASGKPK ISAHRKLISS DYYIWNSKAP
481 APVTYGSLLLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against AP5M1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.28
- Highest tissue expression
- 30 nTPM
Expression across tissuesHPA
Tissue
- parathyroid gland: 30 nTPM
- rectum: 28 nTPM
- duodenum: 27 nTPM
- kidney: 27 nTPM
- tongue: 26 nTPM
- colon: 24 nTPM
Single-cell type
- early spermatids: 196 nCPM
- late spermatids: 143 nCPM
- choroid plexus epithelial cells: 119 nCPM
- parietal cells: 88 nCPM
- tuft cells: 81 nCPM
- retinal pigment epithelial cells: 77 nCPM
Immune cell
- eosinophil: 37 nTPM
- NK-cell: 29 nTPM
- T-reg: 26 nTPM
- myeloid DC: 25 nTPM
- memory B-cell: 23 nTPM
- naive CD8 T-cell: 23 nTPM
Brain region
- choroid plexus: 55 nTPM
- hypothalamus: 41 nTPM
- pons: 39 nTPM
- cerebellum: 37 nTPM
- white matter: 34 nTPM
- medulla oblongata: 34 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about AP5M1.
Disease | GeneticClinVar
2 pathogenic / likely-pathogenic of 71 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.09
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.13
- DepMap mean gene effect
- 0
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads AP5M1 as an antibody target. Whether an autoantibody or antibody against AP5M1 could matter depends on whether native AP5M1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
AP5M1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label AP5M1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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