P2X purinoreceptor extracellular domain superfamily

Definition

P2X purinoceptors are cell membrane ion channels, gated by adenosine 5'-triphosphate (ATP) and other nucleotides. P2X purinoceptor adopts a chalice-shaped, homotrimetric architecture consisting of a large hydrophilic and glycosylated extracellular domain, a transmembrane domain composed of 6 α-helices and short intracellular amino and carboxy termini [[cite:PMID:22535247], [cite:PMID:1964158]]. This superfamily represents the extracellular domain which is characterised by a transthyretin-like β-sandwich motif PMID:671542. This domain contains binding sites for ATP, competitive antagonists and modulatory metal ions PMID:20227116.

7 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (7 proteins: gene, accession, name)

• P2RX1
• P2RX2
• P2RX3
• P2RX4
• P2RX5
• P2RX6
• P2RX7