Seroatlas · Human Serome Atlas

P2RX6

P2X purinoceptor 6

Also known as: MGC129625, P2RX6_HUMAN, P2RXL1, P2X6, P2XM

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O15547
Gene
P2RX6
Ensembl
ENSG00000099957
Chromosome
22
Canonical length
441 aa
Protein class
Predicted membrane proteins
Subcellular location
Nucleoli,Cytosol
Quaternary structure
Homotrimer

OverviewNCBI Gene

The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified. [provided by RefSeq, Apr 2009]

Canonical amino-acid sequenceUniProt

441 residues, UniProt reviewed canonical sequence.

>O15547|P2RX6
     1  MCPQLAGAGS MGSPGATTGW GLLDYKTEKY VMTRNWRVGA LQRLLQFGIV VYVVGWALLA
    61  KKGYQERDLE PQFSIITKLK GVSVTQIKEL GNRLWDVADF VKPPQGENVF FLVTNFLVTP
   121  AQVQGRCPEH PSVPLANCWV DEDCPEGEGG THSHGVKTGQ CVVFNGTHRT CEIWSWCPVE
   181  SGVVPSRPLL AQAQNFTLFI KNTVTFSKFN FSKSNALETW DPTYFKHCRY EPQFSPYCPV
   241  FRIGDLVAKA GGTFEDLALL GGSVGIRVHW DCDLDTGDSG CWPHYSFQLQ EKSYNFRTAT
   301  HWWEQPGVEA RTLLKLYGIR FDILVTGQAG KFGLIPTAVT LGTGAAWLGV VTFFCDLLLL
   361  YVDREAHFYW RTKYEEAKAP KATANSVWRE LALASQARLA ECLRRSSAPA PTATAAGSQT
   421  QTPGWPCPSS DTHLPTHSGS L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against P2RX6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
32 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 32 nTPM
  • tongue: 11 nTPM
  • cerebral cortex: 6.5 nTPM
  • spleen: 6.3 nTPM
  • pituitary gland: 5.7 nTPM
  • choroid plexus: 4.1 nTPM

Single-cell type

  • myonuclei: 55 nCPM
  • myosatellite cells: 31 nCPM
  • retinal ganglion cells: 27 nCPM
  • corticotrophs: 16 nCPM
  • choroid plexus epithelial cells: 16 nCPM
  • sertoli cells: 15 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • pons: 15 nTPM
  • cerebral cortex: 13 nTPM
  • medulla oblongata: 11 nTPM
  • hypothalamus: 10 nTPM
  • cerebellum: 8.1 nTPM
  • white matter: 7.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.1
gnomAD pLI
0
gnomAD missense Z
0.84
DepMap mean gene effect
0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of P2RX6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads P2RX6 as an antibody target. Whether an autoantibody or antibody against P2RX6 could matter depends on whether native P2RX6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

P2RX6 is annotated at the cell surface, where native P2RX6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label P2RX6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/P2RX6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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