Seroatlas · Human Serome Atlas

P2RX3

P2X purinoceptor 3

Also known as: P2RX3_HUMAN, P2X3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P56373
Gene: P2RX3
Ensembl: ENSG00000109991
Chromosome: 11
Canonical length: 397 aa
Protein class: Predicted membrane proteins, Transporters
Quaternary structure: Homotrimer

OverviewNCBI Gene

This gene encodes a member of the P2X purinergic receptor (purinoceptor) gene family which includes seven members (P2RX1 - P2RX7). P2X purinoceptors are a family of cation-permeable, ligand-gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP). The encoded protein is a subunit of the trimeric P2X3 receptor ion channel which is expressed by sensory or autonomic neurons. A deficiency of the orthologous protein in mice is associated with reduced pain-related behavior and urinary bladder hyporeflexia. [provided by RefSeq, Aug 2017]

Canonical amino-acid sequenceUniProt

397 residues, UniProt reviewed canonical sequence.

>P56373|P2RX3
     1  MNCISDFFTY ETTKSVVVKS WTIGIINRVV QLLIISYFVG WVFLHEKAYQ VRDTAIESSV
    61  VTKVKGSGLY ANRVMDVSDY VTPPQGTSVF VIITKMIVTE NQMQGFCPES EEKYRCVSDS
   121  QCGPERLPGG GILTGRCVNY SSVLRTCEIQ GWCPTEVDTV ETPIMMEAEN FTIFIKNSIR
   181  FPLFNFEKGN LLPNLTARDM KTCRFHPDKD PFCPILRVGD VVKFAGQDFA KLARTGGVLG
   241  IKIGWVCDLD KAWDQCIPKY SFTRLDSVSE KSSVSPGYNF RFAKYYKMEN GSEYRTLLKA
   301  FGIRFDVLVY GNAGKFNIIP TIISSVAAFT SVGVGTVLCD IILLNFLKGA DQYKAKKFEE
   361  VNETTLKIAA LTNPVYPSDQ TTAEKQSTDS GAFSIGH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against P2RX3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 3.9 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 3.9 nTPM
testis: 3.1 nTPM
liver: 1.6 nTPM
skeletal muscle: 0.8 nTPM
stomach: 0.5 nTPM
retina: 0.4 nTPM

Single-cell type

early spermatids: 99 nCPM
late spermatids: 40 nCPM
pericytes: 14 nCPM
late primary spermatocytes: 7 nCPM
retinal bipolar cells: 2.9 nCPM
respiratory ionocytes: 2.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

spinal cord: 0.5 nTPM
medulla oblongata: 0.3 nTPM
midbrain: 0.2 nTPM
pons: 0.2 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0
gnomAD missense Z: 1.27
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads P2RX3 as an antibody target. Whether an autoantibody or antibody against P2RX3 could matter depends on whether native P2RX3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

P2RX3 is annotated at the cell surface, where native P2RX3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label P2RX3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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