Seroatlas · Human Serome Atlas

P2RX7

P2X purinoceptor 7

Also known as: MGC20089, P2RX7_HUMAN, P2X7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99572
Gene
P2RX7
Ensembl
ENSG00000089041
Chromosome
12
Canonical length
595 aa
Protein class
Predicted membrane proteins, Transporters
Quaternary structure
Homotrimer

OverviewNCBI Gene

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010]

Canonical amino-acid sequenceUniProt

595 residues, UniProt reviewed canonical sequence.

>Q99572|P2RX7
     1  MPACCSCSDV FQYETNKVTR IQSMNYGTIK WFFHVIIFSY VCFALVSDKL YQRKEPVISS
    61  VHTKVKGIAE VKEEIVENGV KKLVHSVFDT ADYTFPLQGN SFFVMTNFLK TEGQEQRLCP
   121  EYPTRRTLCS SDRGCKKGWM DPQSKGIQTG RCVVYEGNQK TCEVSAWCPI EAVEEAPRPA
   181  LLNSAENFTV LIKNNIDFPG HNYTTRNILP GLNITCTFHK TQNPQCPIFR LGDIFRETGD
   241  NFSDVAIQGG IMGIEIYWDC NLDRWFHHCR PKYSFRRLDD KTTNVSLYPG YNFRYAKYYK
   301  ENNVEKRTLI KVFGIRFDIL VFGTGGKFDI IQLVVYIGST LSYFGLAAVF IDFLIDTYSS
   361  NCCRSHIYPW CKCCQPCVVN EYYYRKKCES IVEPKPTLKY VSFVDESHIR MVNQQLLGRS
   421  LQDVKGQEVP RPAMDFTDLS RLPLALHDTP PIPGQPEEIQ LLRKEATPRS RDSPVWCQCG
   481  SCLPSQLPES HRCLEELCCR KKPGACITTS ELFRKLVLSR HVLQFLLLYQ EPLLALDVDS
   541  TNSRLRHCAY RCYATWRFGS QDMADFAILP SCCRWRIRKE FPKSEGQYSG FKSPY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against P2RX7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 17 nTPM
  • hippocampal formation: 14 nTPM
  • midbrain: 13 nTPM
  • skin: 12 nTPM
  • cerebral cortex: 12 nTPM
  • amygdala: 8.5 nTPM

Single-cell type

  • oligodendrocytes: 350 nCPM
  • melanocytes: 195 nCPM
  • oligodendrocyte progenitor cells: 187 nCPM
  • microglia: 152 nCPM
  • cdc: 109 nCPM
  • macrophages: 84 nCPM

Immune cell

  • intermediate monocyte: 4.5 nTPM
  • non-classical monocyte: 3.3 nTPM
  • classical monocyte: 2.9 nTPM
  • myeloid DC: 2.6 nTPM
  • T-reg: 1.4 nTPM
  • gdT-cell: 1.3 nTPM

Brain region

  • white matter: 80 nTPM
  • medulla oblongata: 43 nTPM
  • basal ganglia: 43 nTPM
  • pons: 42 nTPM
  • thalamus: 38 nTPM
  • cerebral cortex: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.92
gnomAD pLI
0
gnomAD missense Z
0.4
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of P2RX7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads P2RX7 as an antibody target. Whether an autoantibody or antibody against P2RX7 could matter depends on whether native P2RX7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

P2RX7 is annotated at the cell surface, where native P2RX7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label P2RX7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/P2RX7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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