Seroatlas · Human Serome Atlas

P2RX5

P2X purinoceptor 5

Also known as: LRH-1, P2RX5_HUMAN, P2X5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q93086
Gene: P2RX5
Ensembl: ENSG00000083454
Chromosome: 17
Canonical length: 444 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Plasma membrane,Cytosol
Quaternary structure: Homotrimer

OverviewNCBI Gene

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream gene, TAX1BP3 (Tax1 binding protein 3). [provided by RefSeq, Mar 2011]

Canonical amino-acid sequenceUniProt

444 residues, UniProt reviewed canonical sequence.

>Q93086|P2RX5
     1  MGQAGCKGLC LSLFDYKTEK YVIAKNKKVG LLYRLLQASI LAYLVVWVFL IKKGYQDVDT
    61  SLQSAVITKV KGVAFTNTSD LGQRIWDVAD YVIPAQGENV FFVVTNLIVT PNQRQNVCAE
   121  NEGIPDGACS KDSDCHAGEA VTAGNGVKTG RCLRRENLAR GTCEIFAWCP LETSSRPEEP
   181  FLKEAEDFTI FIKNHIRFPK FNFSKSNVMD VKDRSFLKSC HFGPKNHYCP IFRLGSVIRW
   241  AGSDFQDIAL EGGVIGINIE WNCDLDKAAS ECHPHYSFSR LDNKLSKSVS SGYNFRFARY
   301  YRDAAGVEFR TLMKAYGIRF DVMVNGKAGK FSIIPTIINV GSGVALMGAG AFFCDLVLIY
   361  LIKKREFYRD KKYEEVRGLE DSSQEAEDEA SGLGLSEQLT SGPGLLGMPE QQELQEPPEA
   421  KRGSSSQKGN GSVCPQLLEP HRST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against P2RX5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 74 nTPM

Expression across tissuesHPA

Tissue

lymph node: 74 nTPM
spleen: 53 nTPM
tonsil: 51 nTPM
appendix: 30 nTPM
small intestine: 24 nTPM
skeletal muscle: 17 nTPM

Single-cell type

b-cells: 1.7 nCPM
thymic myoid cells: 1.4 nCPM
megakaryocyte-erythroid progenitors: 1.3 nCPM
plasma cells: 1.2 nCPM
thymocytes: 0.8 nCPM
innate lymphoid cells: 0.2 nCPM

Immune cell

naive B-cell: 86 nTPM
memory B-cell: 77 nTPM
total PBMC: 4.5 nTPM
MAIT T-cell: 4.3 nTPM
gdT-cell: 3.1 nTPM
memory CD4 T-cell: 2.8 nTPM

Brain region

cerebral cortex: 10 nTPM
basal ganglia: 8.4 nTPM
white matter: 6.7 nTPM
amygdala: 6.3 nTPM
hypothalamus: 6 nTPM
hippocampal formation: 5.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.27
gnomAD pLI: 0
gnomAD missense Z: -0.74
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads P2RX5 as an antibody target. Whether an autoantibody or antibody against P2RX5 could matter depends on whether native P2RX5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

P2RX5 is annotated at the cell surface, where native P2RX5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label P2RX5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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