Seroatlas · Human Serome Atlas

P2RX1

P2X purinoceptor 1

Also known as: P2RX1_HUMAN, P2X1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P51575
Gene
P2RX1
Ensembl
ENSG00000108405
Chromosome
17
Canonical length
399 aa
Protein class
Predicted membrane proteins
Subcellular location
Endoplasmic reticulum

OverviewNCBI Gene

The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. [provided by RefSeq, Jun 2013]

Canonical amino-acid sequenceUniProt

399 residues, UniProt reviewed canonical sequence.

>P51575|P2RX1
     1  MARRFQEELA AFLFEYDTPR MVLVRNKKVG VIFRLIQLVV LVYVIGWVFL YEKGYQTSSG
    61  LISSVSVKLK GLAVTQLPGL GPQVWDVADY VFPAQGDNSF VVMTNFIVTP KQTQGYCAEH
   121  PEGGICKEDS GCTPGKAKRK AQGIRTGKCV AFNDTVKTCE IFGWCPVEVD DDIPRPALLR
   181  EAENFTLFIK NSISFPRFKV NRRNLVEEVN AAHMKTCLFH KTLHPLCPVF QLGYVVQESG
   241  QNFSTLAEKG GVVGITIDWH CDLDWHVRHC RPIYEFHGLY EEKNLSPGFN FRFARHFVEN
   301  GTNYRHLFKV FGIRFDILVD GKAGKFDIIP TMTTIGSGIG IFGVATVLCD LLLLHILPKR
   361  HYYKQKKFKY AEDMGPGAAE RDLAATSSTL GLQENMRTS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against P2RX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
150 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 150 nTPM
  • urinary bladder: 83 nTPM
  • pancreas: 61 nTPM
  • bone marrow: 40 nTPM
  • seminal vesicle: 32 nTPM
  • esophagus: 22 nTPM

Single-cell type

  • platelets: 509 nCPM
  • smooth muscle cells: 254 nCPM
  • mast cells: 241 nCPM
  • neutrophils: 196 nCPM
  • pdcs: 193 nCPM
  • neutrophil progenitors: 180 nCPM

Immune cell

  • non-classical monocyte: 47 nTPM
  • neutrophil: 24 nTPM
  • intermediate monocyte: 20 nTPM
  • plasmacytoid DC: 15 nTPM
  • eosinophil: 12 nTPM
  • classical monocyte: 11 nTPM

Brain region

  • white matter: 1.2 nTPM
  • midbrain: 1.1 nTPM
  • cerebellum: 1 nTPM
  • medulla oblongata: 0.9 nTPM
  • pons: 0.9 nTPM
  • basal ganglia: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.21
gnomAD pLI
0
gnomAD missense Z
1.02
DepMap mean gene effect
-0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads P2RX1 as an antibody target. Whether an autoantibody or antibody against P2RX1 could matter depends on whether native P2RX1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

P2RX1 is annotated at the cell surface, where native P2RX1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label P2RX1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/P2RX1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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