NUT family
IPR024310
Definition
The gene encoding Nuclear Testis (NUT) protein is found fused to BRD3 or BRD4 genes in some aggressive types of carcinoma due to chromosomal translocations [[cite:PMID:12543779], [cite:PMID:17934517]]. Proteins of the BRD family contain two bromodomains that bind transcriptionally active chromatin through associations with acetylated histones H3 and H4 [[cite:PMID:12543779], [cite:PMID:17934517]]. Such proteins are crucial for the regulation of cell cycle progression. On the other hand, little is known about NUT protein function.
7 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Loading the interactive Seroatlas explorer...