Seroatlas · Human Serome Atlas

NUTM2E

NUT family member 2E

Also known as: FAM22E, NTM2E_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: B1AL46
Gene: NUTM2E
Ensembl: ENSG00000228570
Chromosome: 10
Canonical length: 878 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear bodies

OverviewNCBI Gene

No narrative summary is available for NUTM2E in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

878 residues, UniProt reviewed canonical sequence.

>B1AL46|NUTM2E
     1  MEVKGPSGRS FCCESEGQFK SCLKRHTPSL LLPSSWKGNS GSCLMAEALH RTSPTPNSCP
    61  LPLPLCRMSG VLCSRNLFTF KFSLFQLDSG ASGEPGHSLG LTLGFSYCGN CQTAVVSAQP
   121  EGMASNGAYP VLGPGVTANP GTSLSVFTAL PFTTPAPGPA HGPLLVTAGA PPGGPLVLST
   181  FPSTPLVTEQ DGCSPSGAGA SNVFVQMRTE VGPVKAAQAQ TLVLTQAPLV WQAPGALCGG
   241  VVCPPPLLLA AAPVVPVMAA QVVGGTQACE GGWSQGLPLP PPPPPAAQLP PIVSQGNAGP
   301  WPQGAHGESS LASSQAKAPP DDSCNPRSVY ENFRLWQHYK PLARRHLPQS PDTEALSCFL
   361  IPVLRSLARR KPTMTLEEGL WRAMREWQHT SNFDRMIFYE MAEKFLEFEA EEEMQIQKSQ
   421  WMKGPQCLPP PATPRLEPRG PPAPEVVKQP VYLPSKAGPK AQTACLPPPR PQRPVTKARR
   481  PPPQPHRRAE TKARLPPPRP QRPAETKVPE EIPPEVVQEY VDIMEELLGP SLGATGEPEK
   541  QREEGKVKQP QEEDWTPPDP GLLSYIDKLC SQKDFVTKVE AVIHPQFLEE LLSPDPQMDF
   601  LALSQDLEQE EGLTLAQLVE KRLPPLKEKQ HSRAAPSRGT ARLDSSSSKF AAGQGAERDV
   661  PDPQEGVGME TCPPQTTARD SQGRGRAHTG MARSEDSVVL LGCQDSPGLR AARPTSPPQD
   721  HRPTCPGVGT KDALDLPGGS PVRESHGLAQ GSSEEEELPS LAFLLGSQHK LLPWWLPQSP
   781  VPASGLLSPE KWGPQGTHQS PSAERRGLNL APSPANKAKK QPLFGSLSPA EKTPHRGPGL
   841  RVSGEQSLTW GLGGPSQSQK RKGDPLVSRK EKKQHCSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUTM2E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 4.8 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 4.8 nTPM
cerebral cortex: 3.5 nTPM
parathyroid gland: 3.3 nTPM
testis: 3.2 nTPM
pancreas: 3 nTPM
tongue: 3 nTPM

Single-cell type

adrenal medulla cells: 21 nCPM
retinal horizontal cells: 20 nCPM
pdcs: 14 nCPM
adipocytes: 11 nCPM
epididymal principal cells: 10 nCPM
thymic myoid cells: 9.5 nCPM

Immune cell

eosinophil: 5.3 nTPM
basophil: 3.8 nTPM
neutrophil: 2.9 nTPM
naive CD4 T-cell: 2.4 nTPM
classical monocyte: 2.1 nTPM
NK-cell: 2.1 nTPM

Brain region

white matter: 25 nTPM
cerebral cortex: 21 nTPM
thalamus: 20 nTPM
basal ganglia: 20 nTPM
medulla oblongata: 19 nTPM
cerebellum: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.94
gnomAD pLI: 0
gnomAD missense Z: -1.04

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUTM2E as an antibody target. Whether an autoantibody or antibody against NUTM2E could matter depends on whether native NUTM2E is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUTM2E is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUTM2E as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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