Seroatlas · Human Serome Atlas

NUTM2D

NUT family member 2D

Also known as: FAM22D, NTM2D_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5VT03
Gene
NUTM2D
Ensembl
ENSG00000214562
Chromosome
10
Canonical length
806 aa
Protein class
Cancer-related genes, Predicted intracellular proteins
Subcellular location
Nuclear bodies

OverviewNCBI Gene

No narrative summary is available for NUTM2D in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

806 residues, UniProt reviewed canonical sequence.

>Q5VT03|NUTM2D
     1  MFQEPVYFQI FLFQLDSGAS GEPGHSLGLT LGFSHCGNCQ TAVVSAQPEG MASNGAYPAL
    61  GPGVTANPGT SLSVFTALPF TTPAPGPAHG PLLVTAGAPP GGPLVLSNFP STPLVTEQDG
   121  CGPSGAGASN VFVQMRTEVG PVKAAQAQTL VLTQTPLVWQ APGALCGGVV CPPPLLLAAA
   181  PVVPVMAAQV VGGTQACEGG WSQGLPLPPP PPPAAQLPPI VSQGNAGPWP QGAHGEGSLA
   241  SSQAKAPPDD SCNPRSVYEN FRLWQHYKPL ARRHLPQSPD TEALSCFLIP VLRSLARRKP
   301  TMTLEEGLWR AMREWQHTSN FDRMIFYEMA EKFLEFEAEE EMQIQKSQWM KGPQCLPPPA
   361  TPRLEPRGPP APEVVKQPVY LPSKAGPKAP TACLPPPRPQ RPVTKARRPP PRPHRRAETK
   421  ARLPPPRPQR PAETKVPEEI PPEVVQEYVD IMEELLGPSL GATGEPEKQR EEGEVKQPQE
   481  EDWTPPDPGL LSYTDKLCSQ KDFVTKVEAV IHPQFLEELL SPDPQMDFLA LSQELEQEEG
   541  LTLAQLVEKR LLPLKEKQHA RAAPSRGTAR LDSSSSKFAA GQGAERDVPD PQQGVGMETC
   601  PPQTTARDSQ GRGRAHTGMA RSKDSVVLLG CQDSPGLRAA RPTSPPQDHR PTCPGVGTKD
   661  ALDLPGGSPV RESHGLAQGS SEEEELPSLA FLLGSQHKLL PWWLPQSPVP ASGLLSPEKW
   721  GPQGTHQSPS AERRGLNLAP SPANKAKKRP LFGSLSPAEK TPHPGPGLRV SGEQSLTWGL
   781  GGPSQSQKRK GDPLVSRKEK KQRCSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUTM2D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
6.8 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 6.8 nTPM
  • hippocampal formation: 6 nTPM
  • midbrain: 5.6 nTPM
  • heart muscle: 5.5 nTPM
  • amygdala: 5.4 nTPM
  • kidney: 5.1 nTPM

Single-cell type

  • epicardial cells: 9.1 nCPM
  • cardiomyocytes: 4.5 nCPM
  • retinal ganglion cells: 3.9 nCPM
  • adipocytes: 1.1 nCPM
  • endometrial secretory cells: 1 nCPM
  • vascular smooth muscle cells: 0.9 nCPM

Immune cell

  • eosinophil: 0.1 nTPM
  • naive B-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • white matter: 33 nTPM
  • cerebral cortex: 32 nTPM
  • medulla oblongata: 29 nTPM
  • basal ganglia: 27 nTPM
  • thalamus: 27 nTPM
  • pons: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.99
gnomAD pLI
0.37
gnomAD missense Z
0.1

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUTM2D as an antibody target. Whether an autoantibody or antibody against NUTM2D could matter depends on whether native NUTM2D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUTM2D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUTM2D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NUTM2D. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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