Seroatlas · Human Serome Atlas

NUTM2A

NUT family member 2A

Also known as: FAM22A, NTM2A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IVF1
Gene
NUTM2A
Ensembl
ENSG00000184923
Chromosome
10
Canonical length
878 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear bodies

OverviewNCBI Gene

No narrative summary is available for NUTM2A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

878 residues, UniProt reviewed canonical sequence.

>Q8IVF1|NUTM2A
     1  MEVKGPSGRS FCCESEGQFK SCLKRHTPSL LLPSSWKGNS GSCLMAKALH RMSPTPNSCP
    61  LPLPLCRMSG VLCSRNLFTF KFSLFQLDSG ASGEPGHSLG LTLGFSHCGN CQTAVVSAQP
   121  EGMASNGAYP ALGPGVTANP GTSLSVFTAL PFTTPAPGPA HGPLLVTAGA PPGGPLVLST
   181  LPSTPLVTEQ DGCGPSGAGA SNVFVQMRTE VGPVKAAQAQ TLVLTQAPLV WQAPGALCGG
   241  VVCPPPLLLA AAPVVPVMAA QVVGGTQACE GGWSQGLPLP PPPPPAAQLP PIVSQGNAGP
   301  WPQGAHGEGS LASSQAKAPP DDSCNPRSVY ENFRLWQHYK PLARRHLPQS PDTEALSCFL
   361  IPVLRSLARR KPTMTLEEGL WRAMREWQHT SNFDRMIFYE MAEKFLEFEA EEEMQIQKSQ
   421  WMKGPQCLPP PATPRLEPRG PPAPEVVKQP VYLPSKAGPK APTACLPPPR PQRPVTKARR
   481  PPPRPHRRAE TKARLPPPRP QRPAETKVPE EIPPEVVQEY VDIMEELLGP SLGATGEPEK
   541  QREEGEVKQP QEEDWTPPDP GLLSYTDKLC SQKDFVTKVE AVIHPQFLEE LLSPDPQMDF
   601  LALSQELEQE EGLTLAQLVE KRLLPLKEKQ HARAAPSRGT ARLDSSSSKF AAGQGAERDV
   661  PVPQQGVGME TCPPQTTARD SQGRGRAHTG MARSKDSVVL LGCQDSPGLR AARPTSPPQD
   721  HRPTCPGVGT KDALDLPGGS PVRESHGLAQ GSSEEEELPS LAFLLGSQHK LLPWWLPQSP
   781  VPASGLLSPE KWGPQGTHQF PSAERRGLNL APSPANKAKK RPLFGSLSPA EKTPHPGPGL
   841  RVSGEQSLTW GLGGPSQSQK RKGDPLVSRK EKKQRCSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUTM2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
2.5 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 2.5 nTPM
  • hippocampal formation: 2.1 nTPM
  • heart muscle: 2 nTPM
  • midbrain: 2 nTPM
  • amygdala: 1.9 nTPM
  • testis: 1.8 nTPM

Single-cell type

  • epicardial cells: 6.8 nCPM
  • cardiomyocytes: 4.2 nCPM
  • cone photoreceptor cells: 2.1 nCPM
  • adipocytes: 2 nCPM
  • mucous neck cells: 1.2 nCPM
  • gastric chief cells: 1.1 nCPM

Immune cell

  • eosinophil: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 13 nTPM
  • cerebral cortex: 12 nTPM
  • medulla oblongata: 12 nTPM
  • thalamus: 11 nTPM
  • basal ganglia: 11 nTPM
  • pons: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.94
gnomAD pLI
0
gnomAD missense Z
0.63
DepMap mean gene effect
-0.42
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUTM2A as an antibody target. Whether an autoantibody or antibody against NUTM2A could matter depends on whether native NUTM2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUTM2A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUTM2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NUTM2A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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