Seroatlas · Human Serome Atlas

NUTM2F

NUT family member 2F

Also known as: DKFZp434I1117, FAM22F, NTM2F_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A1L443
Gene: NUTM2F
Ensembl: ENSG00000130950
Chromosome: 9
Canonical length: 756 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear bodies

OverviewNCBI Gene

No narrative summary is available for NUTM2F in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

756 residues, UniProt reviewed canonical sequence.

>A1L443|NUTM2F
     1  MASNGAYPVL GPGVTVNPGT SLSVFTALPF ATPAPGPAHR PPLVTAVVPP AGPLVLSAFP
    61  STPLVAGQDG RGPSGAGASN VFVQMRTEVG PVKPPQAQTL ILTQAPLVWQ APGTLCGGVM
   121  CPPPLLLAAA PGVPVTSAQV VGGTQACEGG WSHGLPLPPP PPAAQVAPIV SPGNARPWPQ
   181  GAHGEGSLAP SQAKARPDDS CKPKSVYENF RLWQHYKPLA RRHLPQSPDT EALSCFLIPV
   241  LRSLARRKPT MTLEEGLWQA MREWQHTSNF DRMIFYEMAE KFLEFEAEEE MQIQKSQWMK
   301  GPQSLPPPAP PRLEPRGPPA PEVVKQPVYL PSKDGPKAPT ACLPPPRPQR PAETKAHLPP
   361  PRPQRPAETN AHLPPPRPQR PAETKVPEEI PPEVVQEYVD IMEELLGSHP GDTGEPEGQR
   421  EKGKVEQPQE EDGITSDPGL LSYIDKLCSQ EDFVTKVEAV IHPRFLEELL SPDPQMDFLA
   481  LSQELEQEEG LTLAQLVEKR LLSLKEKGCG RAAPRHGTAR LDSSPSEFAA GQEAAREVPD
   541  PQQRVSVETS PPQTAAQDPQ GQGRVRTGMA RSEDPAVLLG CQDSPRLKAV RPTSPPQDHR
   601  PTCPGLGTKD ALGLPGESPV KESHGLAKGS SEETELPGMV YVVGSHHRLR PWRLSQSPVP
   661  SSGLLSPGGR GPQGALQSPS AQKRGLSPSP SPASKSKKRP LFGSPSPAEK TPHPGPGLRV
   721  SGEQSLAWGL GGPSQSQKRK GDPLASRRKK KRHCSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUTM2F can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 1.8 nTPM

Expression across tissuesHPA

Tissue

testis: 1.8 nTPM
choroid plexus: 0.1 nTPM
kidney: 0.1 nTPM
liver: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

epididymal clear cells: 2 nCPM
kupffer cells: 1 nCPM
podocytes: 0.8 nCPM
cardiomyocytes: 0.4 nCPM
differentiating spermatogonia: 0.4 nCPM
late primary spermatocytes: 0.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.5 nTPM
pons: 0.3 nTPM
white matter: 0.3 nTPM
amygdala: 0.2 nTPM
basal ganglia: 0.2 nTPM
cerebellum: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0
gnomAD missense Z: -0.41
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUTM2F as an antibody target. Whether an autoantibody or antibody against NUTM2F could matter depends on whether native NUTM2F is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUTM2F is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUTM2F as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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