Seroatlas · Human Serome Atlas

NUTM2B

NUT family member 2B

Also known as: bA119F19.1, FAM22B, NTM2B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NNL0
Gene: NUTM2B
Ensembl: ENSG00000188199
Chromosome: 10
Canonical length: 878 aa
Protein class: Cancer-related genes, Predicted intracellular proteins
Subcellular location: Nuclear bodies

OverviewNCBI Gene

No narrative summary is available for NUTM2B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

878 residues, UniProt reviewed canonical sequence.

>A6NNL0|NUTM2B
     1  MEVKGPSGRS FCCESEGQFK SCLKRHTPSL LLPSSWKGNS GSCLMAEALH RTSPTPNSCP
    61  LPLPLCRMSG VLCSRNLFTF KFSLFQLDSG ASGEPGHSLG LTLGFSYCGN CQTAVVSAQP
   121  EGMASNGAYP VLGPGVTANP GTSLSVFTAL PFTTPAPGPA HGPLLVTAGA PPGGPLVLST
   181  FPSTPLVTEQ DGCGPSGAGA SNVFVQMRTE VGPVKAAQAQ TLVLTQAPLV WQAPGALCGG
   241  VVCPPPLLLA AAPVVPVMAA QVVGGTQACE GGWSQGLPLP PPPPPAAQLP PIVSQGNAGP
   301  WPQGAHGESS LASSQAKAPP DDSCNPRSVY ENFRLWQHYK PLARRHLPQS PDTEALSCFL
   361  IPVLRSLARR KPTMTLEEGL WRAMREWQHT SNFDRMIFYE MAEKFLEFEA EEEMQIQKSQ
   421  WMKGPQCLPP PATPRLEPRG PPAPEVVKQP VYLPSKAGPK APTACLPPPR PQRPVTKARR
   481  PPPRPHRRAE TKARLPPPRP QRPAETKVPE EIPPEVVQEY VDIMEELLGP SLGATGEPEK
   541  QREEGKVKQP QEEDWTPPDP GLLSYIDKLC SQKDFVTKVE AVIHPQFLEE LLSPDPQMDF
   601  LALSQDLEQE EGLTLAQLVE KRLPPLKEKQ HARAAPSRGT ARLDSSSSKF AAGQGAERDV
   661  PDPQQGVGME TCPPQMTARD SQGRGRAHTG MARSEDSVVL LGCQDSPGLR AAWPTSPPQD
   721  HRPTCPGVGT KDALDLPGGS PVRESHGLAQ GSSEEEELPS LAFLLGSQHK LLPWWLPQSP
   781  VPASGLLSPE KWGPQGTHQS PSAERRGLNL APSPANKAKK RPLFGSLSPA EKTPYPGPGL
   841  RVSGEQSLTW GLGGPSQSQK RKGDPLVSRK EKKQHCSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUTM2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 2.4 nTPM

Expression across tissuesHPA

Tissue

testis: 2.4 nTPM
hippocampal formation: 1.4 nTPM
pituitary gland: 1.4 nTPM
amygdala: 1.2 nTPM
cerebellum: 1.2 nTPM
basal ganglia: 1.1 nTPM

Single-cell type

cardiomyocytes: 5 nCPM
epicardial cells: 2.3 nCPM
thymocytes: 1.7 nCPM
adipocytes: 1 nCPM
vascular smooth muscle cells: 0.7 nCPM
late primary spermatocytes: 0.5 nCPM

Immune cell

eosinophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 10 nTPM
cerebral cortex: 8.5 nTPM
amygdala: 8.1 nTPM
hippocampal formation: 8 nTPM
medulla oblongata: 7.8 nTPM
pons: 7.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.47
gnomAD pLI: 0.02
gnomAD missense Z: 0.89

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUTM2B as an antibody target. Whether an autoantibody or antibody against NUTM2B could matter depends on whether native NUTM2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUTM2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUTM2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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