Seroatlas · Human Serome Atlas

NUTM2G

NUT family member 2G

Also known as: FAM22G, NTM2G_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VZR2
Gene: NUTM2G
Ensembl: ENSG00000188152
Chromosome: 9
Canonical length: 741 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear bodies

OverviewNCBI Gene

No narrative summary is available for NUTM2G in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

741 residues, UniProt reviewed canonical sequence.

>Q5VZR2|NUTM2G
     1  MASNGAYPVL GPGVTVNPGT SLSVFTALPF ATPSPGPTHR PPLVTAVVPP AGPLVLSAFP
    61  STPLVAGQDG RGPSGAGASN VFVQMRTEVG PVKPPQAQTL ILTQAPLVWQ APGTLCGGVM
   121  CPPPLLLAAA PGVPVTSAQV VGGTQACEGG WSHGLPLPPP PPAAQVAPIV SPGNAGPWPQ
   181  GAHGEGSLAP SQAKARPDDS CKPKSVYENF RLWQHYKPLA RRHLPQSPDT EALSCFLIPV
   241  LRSLARRKPT MTLEEGLWRA MREWQHTSNF DRMIFYEMAA KFLEFEAEEE MQIQKSQWMK
   301  GPQSLPPPAP PRLEPRGPPA PEVVKQPVYL PSKDGPKAPT ACLPPPRPQR PAETKAHLPP
   361  PRPPRPAETK VPEEIPPEVV QEYVDIMEEL LGSHPGDTGE PEGQREKGKV EQPQEEDGMT
   421  SDPGLLSYID KLCSQEDFVT KVEAVIHPRF LEELLSPDPQ MDFLALSQEL EQEEGLTLAQ
   481  LVEKRLLSLK EKGCGRAAPR HGTARLDSSP SEFAAGQEAA REVPDPQQRV SVETSPPQTA
   541  AQDPQGQGRV RTGMARSEDP AVLLGCQDSP RLKAVRPTSP PQDHRPTCPG LGTKDALGLP
   601  GESPVKESHG LAKGSSEETE LPGMVYVVGS HHRLRPWRLS QSPVPSSGLL SPGGRGPQGA
   661  LQSPSAQKRG LSPSPSPASK SKKRPLFGSP SPAEKTPHPG PGLRVSGEQS LAWGLGGPSQ
   721  SQKRKGDPLA SRRKKKRHCS Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUTM2G can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 2.6 nTPM

Expression across tissuesHPA

Tissue

testis: 2.6 nTPM
skeletal muscle: 0.7 nTPM
skin: 0.7 nTPM
bone marrow: 0.5 nTPM
cervix: 0.3 nTPM
endometrium: 0.3 nTPM

Single-cell type

epicardial cells: 36 nCPM
cardiomyocytes: 21 nCPM
retinal ganglion cells: 7.7 nCPM
medullary thymic epithelial cells: 4.8 nCPM
oocytes: 4.6 nCPM
myonuclei: 3.4 nCPM

Immune cell

eosinophil: 0.2 nTPM
naive B-cell: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebellum: 9.1 nTPM
white matter: 8.5 nTPM
cerebral cortex: 8 nTPM
medulla oblongata: 7.9 nTPM
basal ganglia: 7.8 nTPM
thalamus: 7.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.27
gnomAD pLI: 0
gnomAD missense Z: -0.39
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUTM2G as an antibody target. Whether an autoantibody or antibody against NUTM2G could matter depends on whether native NUTM2G is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUTM2G is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUTM2G as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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