Carbonic anhydrase, alpha-class
IPR023561
Definition
Carbonic anhydrases (CA: [ec:4.2.1.1]) are zinc metalloenzymes which catalyse the reversible hydration of carbon dioxide to bicarbonate [[cite:PMID:18336305], [cite:PMID:10978542]]. The alpha-CAs are found predominantly in animals but also in bacteria and green algae. There are at least 15 isoforms found in mammals, which can be subdivided into cytosolic CAs (CA-I, CA-II, CA-III, CA-VII and CA XIII), mitochondrial CAs (CA-VA and CA-VB), secreted CAs (CA-VI), membrane-associated (CA-IV, CA-IX, CA-XII and CA-XIV) and those without CA activity, the CA-related proteins (CA-RP VIII, X and XI).
15 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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