Seroatlas · Human Serome Atlas

CA13

Carbonic anhydrase 13

Also known as: CAH13_HUMAN, CAXIII, FLJ37995, MGC59868

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N1Q1
Gene: CA13
Ensembl: ENSG00000185015
Chromosome: 8
Canonical length: 262 aa
Protein class: Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Vesicles

OverviewNCBI Gene

Predicted to enable carbonate dehydratase activity. Predicted to be located in intracellular membrane-bounded organelle and myelin sheath. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

262 residues, UniProt reviewed canonical sequence.

>Q8N1Q1|CA13
     1  MSRLSWGYRE HNGPIHWKEF FPIADGDQQS PIEIKTKEVK YDSSLRPLSI KYDPSSAKII
    61  SNSGHSFNVD FDDTENKSVL RGGPLTGSYR LRQVHLHWGS ADDHGSEHIV DGVSYAAELH
   121  VVHWNSDKYP SFVEAAHEPD GLAVLGVFLQ IGEPNSQLQK ITDTLDSIKE KGKQTRFTNF
   181  DLLSLLPPSW DYWTYPGSLT VPPLLESVTW IVLKQPINIS SQQLAKFRSL LCTAEGEAAA
   241  FLVSNHRPPQ PLKGRKVRAS FH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CA13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

small intestine: 14 nTPM
duodenum: 11 nTPM
parathyroid gland: 8.4 nTPM
stomach: 5.5 nTPM
skin: 5.3 nTPM
gallbladder: 5 nTPM

Single-cell type

enterocytes: 157 nCPM
lacrimal acinar cells: 77 nCPM
mucous neck cells: 75 nCPM
salivary duct cells: 71 nCPM
alveolar cells type 2: 67 nCPM
cone photoreceptor cells: 64 nCPM

Immune cell

basophil: 0.6 nTPM
classical monocyte: 0.6 nTPM
myeloid DC: 0.5 nTPM
eosinophil: 0.3 nTPM
neutrophil: 0.2 nTPM
non-classical monocyte: 0.2 nTPM

Brain region

hypothalamus: 5.6 nTPM
midbrain: 5.3 nTPM
cerebellum: 5.1 nTPM
cerebral cortex: 4.7 nTPM
white matter: 4.6 nTPM
basal ganglia: 4.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.16
gnomAD pLI: 0
gnomAD missense Z: 0.2
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CA13 as an antibody target. Whether an autoantibody or antibody against CA13 could matter depends on whether native CA13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CA13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CA13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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