Seroatlas · Human Serome Atlas

CA11

Carbonic anhydrase-related protein 11

Also known as: CAH11_HUMAN, CARP2, CARPX1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75493
Gene
CA11
Ensembl
ENSG00000063180
Chromosome
19
Canonical length
328 aa
Protein class
Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Vesicles,Microtubules
Secretome location
Secreted in brain

OverviewNCBI Gene

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

328 residues, UniProt reviewed canonical sequence.

>O75493|CA11
     1  MGAAARLSAP RALVLWAALG AAAHIGPAPD PEDWWSYKDN LQGNFVPGPP FWGLVNAAWS
    61  LCAVGKRQSP VDVELKRVLY DPFLPPLRLS TGGEKLRGTL YNTGRHVSFL PAPRPVVNVS
   121  GGPLLYSHRL SELRLLFGAR DGAGSEHQIN HQGFSAEVQL IHFNQELYGN FSAASRGPNG
   181  LAILSLFVNV ASTSNPFLSR LLNRDTITRI SYKNDAYFLQ DLSLELLFPE SFGFITYQGS
   241  LSTPPCSETV TWILIDRALN ITSLQMHSLR LLSQNPPSQI FQSLSGNSRP LQPLAHRALR
   301  GNRDPRHPER RCRGPNYRLH VDGVPHGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CA11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
518 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 518 nTPM
  • amygdala: 424 nTPM
  • basal ganglia: 352 nTPM
  • cerebellum: 348 nTPM
  • hippocampal formation: 317 nTPM
  • midbrain: 131 nTPM

Single-cell type

  • brain excitatory neurons: 86 nCPM
  • epididymal principal cells: 70 nCPM
  • hepatocytes: 58 nCPM
  • retinal bipolar cells: 57 nCPM
  • retinal amacrine cells: 50 nCPM
  • ovarian stromal cells: 44 nCPM

Immune cell

  • plasmacytoid DC: 1.9 nTPM
  • gdT-cell: 1.5 nTPM
  • MAIT T-cell: 1.5 nTPM
  • naive CD4 T-cell: 1.5 nTPM
  • T-reg: 1.5 nTPM
  • naive B-cell: 1.3 nTPM

Brain region

  • cerebral cortex: 316 nTPM
  • basal ganglia: 246 nTPM
  • amygdala: 223 nTPM
  • white matter: 198 nTPM
  • hippocampal formation: 193 nTPM
  • cerebellum: 168 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.79
gnomAD pLI
0
gnomAD missense Z
1.88
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CA11 as an antibody target. Whether an autoantibody or antibody against CA11 could matter depends on whether native CA11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CA11 is annotated as secreted, so native CA11 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CA11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CA11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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