Seroatlas · Human Serome Atlas

CA10

Carbonic anhydrase-related protein 10

Also known as: CA-RPX, CAH10_HUMAN, CARPX, HUCEP-15

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NS85
Gene: CA10
Ensembl: ENSG00000154975
Chromosome: 17
Canonical length: 328 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Vesicles
Secretome location: Secreted in brain

OverviewNCBI Gene

This gene encodes a protein that belongs to the carbonic anhydrase family of zinc metalloenzymes, which catalyze the reversible hydration of carbon dioxide in various biological processes. The protein encoded by this gene is an acatalytic member of the alpha-carbonic anhydrase subgroup, and it is thought to play a role in the central nervous system, especially in brain development. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

328 residues, UniProt reviewed canonical sequence.

>Q9NS85|CA10
     1  MEIVWEVLFL LQANFIVCIS AQQNSPKIHE GWWAYKEVVQ GSFVPVPSFW GLVNSAWNLC
    61  SVGKRQSPVN IETSHMIFDP FLTPLRINTG GRKVSGTMYN TGRHVSLRLD KEHLVNISGG
   121  PMTYSHRLEE IRLHFGSEDS QGSEHLLNGQ AFSGEVQLIH YNHELYTNVT EAAKSPNGLV
   181  VVSIFIKVSD SSNPFLNRML NRDTITRITY KNDAYLLQGL NIEELYPETS SFITYDGSMT
   241  IPPCYETASW IIMNKPVYIT RMQMHSLRLL SQNQPSQIFL SMSDNFRPVQ PLNNRCIRTN
   301  INFSLQGKDC PNNRAQKLQY RVNEWLLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CA10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 120 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 120 nTPM
cerebral cortex: 46 nTPM
retina: 41 nTPM
amygdala: 36 nTPM
hypothalamus: 30 nTPM
hippocampal formation: 23 nTPM

Single-cell type

retinal bipolar cells: 3,104 nCPM
oligodendrocyte progenitor cells: 1,924 nCPM
podocytes: 1,029 nCPM
brain excitatory neurons: 744 nCPM
oocytes: 659 nCPM
distal convoluted tubule cells: 407 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 99 nTPM
pons: 54 nTPM
hypothalamus: 48 nTPM
medulla oblongata: 36 nTPM
cerebral cortex: 34 nTPM
amygdala: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.46
gnomAD pLI: 0.57
gnomAD missense Z: 1.11
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

brain development

Molecular functions

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CA10 as an antibody target. Whether an autoantibody or antibody against CA10 could matter depends on whether native CA10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CA10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CA10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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