Seroatlas · Human Serome Atlas

CA14

Carbonic anhydrase 14

Also known as: CAH14_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9ULX7
Gene
CA14
Ensembl
ENSG00000118298
Chromosome
1
Canonical length
337 aa
Protein class
Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Plasma membrane

OverviewNCBI Gene

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

337 residues, UniProt reviewed canonical sequence.

>Q9ULX7|CA14
     1  MLFSALLLEV IWILAADGGQ HWTYEGPHGQ DHWPASYPEC GNNAQSPIDI QTDSVTFDPD
    61  LPALQPHGYD QPGTEPLDLH NNGHTVQLSL PSTLYLGGLP RKYVAAQLHL HWGQKGSPGG
   121  SEHQINSEAT FAELHIVHYD SDSYDSLSEA AERPQGLAVL GILIEVGETK NIAYEHILSH
   181  LHEVRHKDQK TSVPPFNLRE LLPKQLGQYF RYNGSLTTPP CYQSVLWTVF YRRSQISMEQ
   241  LEKLQGTLFS TEEEPSKLLV QNYRALQPLN QRMVFASFIQ AGSSYTTGEM LSLGVGILVG
   301  CLCLLLAVYF IARKIRKKRL ENRKSVVFTS AQATTEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CA14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
113 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 113 nTPM
  • tongue: 44 nTPM
  • spinal cord: 43 nTPM
  • retina: 37 nTPM
  • skeletal muscle: 32 nTPM
  • midbrain: 22 nTPM

Single-cell type

  • retinal pigment epithelial cells: 196 nCPM
  • müller glia: 170 nCPM
  • melanocytes: 74 nCPM
  • oligodendrocytes: 23 nCPM
  • cardiomyocytes: 11 nCPM
  • hepatocytes: 8.7 nCPM

Immune cell

  • naive B-cell: 0.6 nTPM
  • plasmacytoid DC: 0.6 nTPM
  • intermediate monocyte: 0.5 nTPM
  • memory B-cell: 0.5 nTPM
  • neutrophil: 0.5 nTPM
  • eosinophil: 0.4 nTPM

Brain region

  • choroid plexus: 61 nTPM
  • white matter: 34 nTPM
  • cerebellum: 24 nTPM
  • medulla oblongata: 22 nTPM
  • pons: 21 nTPM
  • basal ganglia: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.46
gnomAD pLI
0
gnomAD missense Z
0.24
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CA14 as an antibody target. Whether an autoantibody or antibody against CA14 could matter depends on whether native CA14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CA14 is annotated at the cell surface, where native CA14 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CA14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CA14. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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